Hydroxy Itraconazole (Mixture of Diastereomers) CAS 112559-91-8
| CAS No. | 112559-91-8 |
| Molecular Formula | C35H38Cl2N8O5 |
| Molecular Weight | 721.63 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Hydroxy Itraconazole (Mixture of Diastereomers) (CAS 112559-91-8), molecular formula C35H38Cl2N8O5 and molecular weight 721.63 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Hydroxy Itraconazole (Mixture of Diastereomers) (C35H38Cl2N8O5) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Hydroxy Itraconazole (Mixture of Diastereomers) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C35H38Cl2N8O5 |
| Molecular Weight | 721.63 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 20.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 8 |
Related Hydroxy Standards
- Hydroxy Itraconazole (Mixture of Diastereomers) (CAS 207970-87-4)
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- 14-β-Hydroxy-7-O-(triethylsilyl) Baccatin III 1,14-Carbonate (CAS 186347-84-2)
- (S)-1-(2-hydroxy-3-(trityloxy)propyl)-4-(((4-methoxyphenyl)diphenylmethyl)amino)pyrimidin-2(1H)-one (CAS 864068-43-9)
Recommended Standards
- (S)-N-(1-(2-(anthracen-9-yl)phenyl)-2-(diphenylphosphanyl)ethyl)-3,5-bis(trifluoromethyl)benzamide (CAS 2011787-22-5)
- N-(2,6-Bis(4-nitrophenyl)-4-oxidodinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl)-1,1,1-trifluoromethanesulfonamide (CAS 1628940-60-2)
- PDI45-Br (CAS 1951445-73-0)
- N-((11bR)-2,6-Bis(4-nitrophenyl)-4-oxidodinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl)-1,1,1-trifluoromethanesulfonamide (CAS 1010799-99-1)
- 6-Ethyl-5-(4-nitrophenyl)-2,4-pyrimidinediamine (CAS 71552-34-6)
- 1-Isopropyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one (CAS 923283-88-9)
- 2-[(2,6-Dichlorobenzyl)oxy]-3-methoxybenzoic acid (CAS 938250-17-0)
- 1796920-05-2 2-Amino-1,6-dihydro-|A-methyl-6-oxo-7H-purine-7-acetic Acid Ethyl Ester (CAS 1796920-05-2)
- N,N-dimethyl-3-nitro-4-(p-tolylthio)benzamide (CAS 303988-18-3)
- 1-(2-Chloroethyl)-1H-1,2,4-triazole (CAS 3236-66-6)
- 1-Nitrosopyrrolidine-d4 (CAS 57371-40-1)
- methyl 1-benzyl-3-formyl-6-methyl-1H-indole-2-carboxylate (CAS 1170477-28-7)
- 2-((4-Chlorophenyl)thio)-4-oxo-4h-pyrido[1,2-a]pyrimidine-3-carbaldehyde (CAS 431924-79-7)
- Acetyl Tetrapeptide-5 (CAS 820959-17-9)
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