Methyl 4-chloro-8-(trifluoromethyl)quinoline-2-carboxylate CAS 1133115-62-4
| CAS No. | 1133115-62-4 |
| Molecular Formula | C12H7ClF3NO2 |
| Molecular Weight | 289.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Methyl 4-chloro-8-(trifluoromethyl)quinoline-2-carboxylate.
Methyl 4-chloro-8-(trifluoromethyl)quinoline-2-carboxylate (CAS 1133115-62-4) is a high-purity analytical reference standard with the molecular formula C12H7ClF3NO2 and a molecular weight of 289.64 g/mol.
Structurally, Methyl 4-chloro-8-(trifluoromethyl)quinoline-2-carboxylate (C12H7ClF3NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 289.64 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures Methyl 4-chloro-8-(trifluoromethyl)quinoline-2-carboxylate under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H7ClF3NO2 |
| Molecular Weight | 289.64 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Methyl Standards
- 5-(2-Chloro-5-(trifluoromethyl)phenoxy)pyrazin-2-amine (CAS 1206970-21-9)
- Methyl 4-chloro-2-(trifluoromethyl)quinoline-3-carboxylate (CAS 1384264-57-6)
- 2-Chloro-1-[1-[3-(trifluoromethyl)phenyl]-1H-1,2,3-triazol-4-yl]ethanone (CAS 1384431-14-4)
- Methyl 4-chloro-7-(trifluoromethyl)quinoline-3-carboxylate (CAS 1448259-68-4)
- N2-(2-Chloro-5-(trifluoromethyl)phenyl)-1,3,5-triazine-2,4-diamine (CAS 175204-34-9)
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Recommended Standards
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- Brimonidine Impurity 8 HCI (CAS 182627-95-8（free base）)
- Semaglutide impurity 93 (CAS CATO-C4X-222693)
Why CATO?
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