8-Fluoro-5-(trifluoromethyl)quinoline CAS 1133115-99-7
| CAS No. | 1133115-99-7 |
| Molecular Formula | C10H5F4N |
| Molecular Weight | 215.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 8-Fluoro-5-(trifluoromethyl)quinoline.
CATO supplies 8-Fluoro-5-(trifluoromethyl)quinoline (CAS 1133115-99-7), a certified reference material (molecular formula C10H5F4N, MW 215.15 g/mol) for analytical method development and quality control.
8-Fluoro-5-(trifluoromethyl)quinoline (C10H5F4N) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 8-Fluoro-5-(trifluoromethyl)quinoline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H5F4N |
| Molecular Weight | 215.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Fluoro Standards
- 2-Fluoro-4-(trifluoromethyl)pyridine-3-carboxylic acid (CAS 1040681-74-0)
- 6-Fluoro-8-(trifluoromethyl)quinoline (CAS 1065074-24-9)
- 4-Fluoro-8-(trifluoromethyl)quinoline (CAS 1473422-60-4)
- 8-Fluoro-2-(trifluoromethyl)quinoline (CAS 1624260-30-5)
- 6-Fluoro-2-(trifluoromethyl)quinoline (CAS 587885-96-9)
- 6-Fluoro-4-(trifluoromethyl)quinoline (CAS 596845-36-2)
- 1-FLUORO-3-TRIFLUOROMETHYL-4-NITROBENZENE 2-(TRIFLUOROMETHYL)-4-FLUORO NITROBENZENE 2-NITRO-5-FLUOROBENZOTRIFLUORIDE 2-NITRO-ALPHA,ALPHA,ALPHA,5-TETRAFLUOROTOLUENE 2-nitro-5-fluorotrifluorotoluene 393-09-9 4-FLUORO-1-NITRO-2-(TRIFLUOROMETHYL)BENZENE 4-FLUORO-2-(TRIFLUOROMETHYL)NITROBENZENE 5-FLUORO-2-NITROBENZOTRIFLUORIDE BENZENE, 4-FLUORO-1-NITRO-2-(TRIFLUOROMETHYL)- PF10165 (CAS 393-09-9)
- 5-Fluoro-3-methoxy-2-nitrobenzoic acid (CAS 1007113-04-3)
Recommended Standards
- (2,3-Difluorobenzoyl)glycine (CAS 1072833-89-6)
- 1,1-Difluoro-3-(4-nitrophenyl)propan-2-one (CAS 1179915-44-6)
- 1-(2,3-Difluoro-6-nitrophenyl)propan-2-one (CAS 121247-16-3)
- 2-[(2,4-difluorophenyl)methylamino]-2-Oxoacetic Acid (CAS 1248263-78-6)
- 2-(2,4-Dioxo-1,3-diazaspiro[4.5]decan-3-yl)-N-(2-ethyl-6-methylphenyl)acetamide (CAS 565207-47-8)
- 93596-81-7 Copper(1+) (~13~C)cyanide DTXSID50504902 (CAS 93596-81-7)
- 2-Methyl-4-piperidin-4-ylpyrimidine dihydrochloride (CAS 949100-33-8)
- N-((3-methyl-1,2,4-oxadiazol-5-yl)methyl)cyclopropanamine (CAS 1179634-23-1)
- Ethyl 2-(3-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl](methyl)amino}-5-cyano-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-1-yl)acetate (CAS 338399-47-6)
- (4-((Benzyloxy)sulfonyl)phenyl)boronic acid (CAS 2096332-18-0)
- 5-Bromo-N-(2,2-dimethylthietan-3-yl)furan-2-carboxamide (CAS 1866969-66-5)
- 3-(Difluoromethyl)-6-formyl-5-iodopicolinonitrile (CAS 1805380-34-0)
- 3-Methylfluoranthene (CAS 1706-01-0)
- Semaglutide impurity 96 (CAS CATO-C4X-222696)
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