Lidocaine EP Impurity E Hydrochloride CAS 1135231-62-7
| CAS No. | 1135231-62-7 |
| Molecular Formula | C20H25N3O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Lidocaine EP Impurity E Hydrochloride (CAS 1135231-62-7) is a certified pharmaceutical impurity reference standard with the molecular formula C20H25N3O2HCl and a molecular weight of 375.90 g/mol.
The molecular framework of Lidocaine EP Impurity E Hydrochloride (C20H25N3O2HCl) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Lidocaine EP Impurity E Hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H25N3O2 HCl |
| Molecular Weight | 375.90 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Lidocaine Standards
- Lidocaine EP Impurity J HCl (CAS 1012864-23-1)
- Lidocaine Impurity 70 HCl (CAS 101651-71-2)
- Lidocaine Impurity 57 (CAS 102878-74-0)
- Lidocaine Impurity 19 (CAS 108-69-0)
- Lidocaine EP Impurity H (CAS 1131-01-7)
- Lidocaine-d10 Hydrochloride (CAS 1189959-13-4)
- Lidocaine EP Impurity D-d6 (CAS 1216698-89-3)
- Lidocaine Impurity 33 (CAS 1374010-02-2)
Recommended Standards
- Serotonin Impurity 9 (CAS CATO-C4X-25349)
- Fesoterodine Impurity N17 (CAS 1254942-29-4)
- Bisoprolol Impurity 22 (CAS 1447715-45-8)
- Tert-butyl (2s,4s)-4-hydroxypyrrolidine-2-carboxylate (CAS 659747-06-5)
- N-(3-Butyl-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)acetamide (CAS 32479-70-2)
- Trametinib impurity 11 (CAS CATO-C4X-278211)
- Triethyl Citrate (CAS 77-93-0)
- Abiraterone Impurity 34 (CAS 571-44-8)
- (1-Methyl-3-(trifluoromethyl)-5-(3-(trifluoromethyl)phenoxy)-1H-pyrazol-4-yl)methyl (4-chlorophenyl)carbamate (CAS 318469-45-3)
- Tau Peptide (337-368) (Repeat 4 Domain) trifluoroacetate salt (CAS 330456-27-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com