N-{4-[(2-Bromoacetyl)amino]phenyl}-2-(2-chlorophenoxy)propanamide CAS 1138443-66-9
| CAS No. | 1138443-66-9 |
| Molecular Formula | C17H16BrClN2O3 |
| Molecular Weight | 411.68 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-{4-[(2-Bromoacetyl)amino]phenyl}-2-(2-chlorophenoxy)propanamide.
N-{4-[(2-Bromoacetyl)amino]phenyl}-2-(2-chlorophenoxy)propanamide (CAS 1138443-66-9) is a high-purity analytical reference standard with the molecular formula C17H16BrClN2O3 and a molecular weight of 411.68 g/mol.
Structurally, N-{4-[(2-Bromoacetyl)amino]phenyl}-2-(2-chlorophenoxy)propanamide (C17H16BrClN2O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine/bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 411.68 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), N-{4-[(2-Bromoacetyl)amino]phenyl}-2-(2-chlorophenoxy)propanamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H16BrClN2O3 |
| Molecular Weight | 411.68 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 2 |
Related N Standards
- 4-[(2-Bromoacetyl)amino]-N-ethyl-N-(1-naphthyl)-benzamide (CAS 1138443-38-5)
- 4-(2-Bromoacetyl)phenyl anthracene-9-carboxylate (CAS 94345-04-7)
- 3-[(2-Bromoacetyl)amino]-N-[3-(trifluoromethyl)-phenyl]benzamide (CAS 1138443-35-2)
- 4-[(2-Bromoacetyl)amino]-N-[3-(trifluoromethyl)-phenyl]benzamide (CAS 1138443-42-1)
- N-(2-(2-Bromoacetyl)-4,5-dimethoxyphenyl)-4-methylbenzenesulfonamide (CAS 886493-98-7)
- 3-(2-Bromoacetyl)-5-chloro-N-(3-methoxypropyl)-2-thiophenesulfonamide (CAS 1174304-97-2)
- N-{3-[(2-Bromoacetyl)amino]phenyl}-4-(tert-butyl)benzamide (CAS 1138443-10-3)
- N-{4-[(2-Bromoacetyl)amino]phenyl}-4-(tert-butyl)benzamide (CAS 886014-23-9)
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- Daclatasvir impurity 39 (CAS CATO-C4X-184839)
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- 3-Amino-3-(4-methyl-5-thiazolyl)propionic Acid (CAS 1507812-87-4)
- Mirabegron Impurity 25 (CAS CATO-C4X-103225)
- 2-Methyl-N-((5-methylfuran-2-yl)methyl)cyclohexan-1-amine (CAS 1019534-32-7)
- SKF 38393 Hydrobromide (CAS 20012-10-6)
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