1-Methyl-1H-1,2,4-triazole-5-carbonitrile CAS 1142927-07-8

Description

Compared with other compounds in its class, the molecular weight of 108.10 g/mol gives 1-Methyl-1H-1,2,4-triazole-5-carbonitrile distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

1-Methyl-1H-1,2,4-triazole-5-carbonitrile (CAS 1142927-07-8), molecular formula C4H4N4 and molecular weight 108.10 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of 1-Methyl-1H-1,2,4-triazole-5-carbonitrile (C4H4N4) is characterized by a nitrile group. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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