(7S)-Cefamandole Impurity 18 CAS 1146611-43-9

Purity >90%In StockPharmacopoeial Impurity Standards
CAS No.1146611-43-9
Molecular FormulaC18H18N6O5S2
Molecular Weight462.50 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

(7S)-Cefamandole Impurity 18 CAS 1146611-43-9 chemical structure

Description

Compared with other compounds in its class, the molecular weight of 462.50 g/mol gives (7S)-Cefamandole Impurity 18 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

CATO supplies (7S)-Cefamandole Impurity 18 (CAS 1146611-43-9), a pharmacopoeial impurity reference standard (molecular formula C18H18N6O5S2, MW 462.50 g/mol) used for the identification and quantification of trace impurities in APIs.

(7S)-Cefamandole Impurity 18 (C18H18N6O5S2) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

As a certified reference material (CRM), (7S)-Cefamandole Impurity 18 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC18H18N6O5S2
Molecular Weight462.50 g/mol
Purity>90%
StorageStore in a cool place (≤25°C), protect from light, keep sealed and dry
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening
Degree of Unsaturation (DBE)13.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1989
Nitrogen Atoms6
Sulfur Atoms2

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