2-chloro-1-(5-fluoro-1H-indol-3-yl)ethan-1-one CAS 115027-06-0
| CAS No. | 115027-06-0 |
| Molecular Formula | C10H15ClFNO |
| Molecular Weight | 219.68 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 2-chloro-1-(5-fluoro-1H-indol-3-yl)ethan-1-one (CAS 115027-06-0), a certified reference material (molecular formula C10H15ClFNO, MW 219.68 g/mol) for analytical method development and quality control.
The molecular framework of 2-chloro-1-(5-fluoro-1H-indol-3-yl)ethan-1-one (C10H15ClFNO) is characterized by an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H15ClFNO |
| Molecular Weight | 219.68 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
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- 4-(Chloromethyl)-1-isopropyl-1H-pyrazole (CAS 1338494-95-3)
- Ethyl 3-amino-5-bromo-2-chlorobenzoate (CAS 1340383-52-9)
- 4-Bromo-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol (CAS 1469979-87-0)
- Ethyl 5-bromo-3-fluoroimidazo[1,2-a]pyridine-2-carboxylate (CAS 2170670-76-3)
- 1-(3-(Benzyl(methyl)amino)pyrrolidin-1-yl)-2-chloroethanone (CAS 1353963-40-2)
- 3-(3-Methylthiophen-2-yl)propanoic acid (CAS 25468-85-3)
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