2,2-difluorocyclobutane-1-carboxylic acid CAS 1150518-74-3
| CAS No. | 1150518-74-3 |
| Molecular Formula | C5H6F2O2 |
| Molecular Weight | 136.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2,2-difluorocyclobutane-1-carboxylic acid (CAS 1150518-74-3) is a high-purity analytical reference standard with the molecular formula C5H6F2O2 and a molecular weight of 136.10 g/mol.
Based on its molecular formula C5H6F2O2, 2,2-difluorocyclobutane-1-carboxylic acid contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic functional-group stretching vibrations in infrared spectroscopy. The molecular weight of 136.10 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2,2-difluorocyclobutane-1-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H6F2O2 |
| Molecular Weight | 136.10 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
Related difluorocyclobutane Standards
- (R)-2,2-Difluorocyclobutane-1-carboxylic acid (CAS 2742942-02-3)
- (S)-2,2-Difluorocyclobutane-1-carboxylic acid (CAS 2750509-66-9)
- 1,3-difluorocyclobutane-1-carboxylic acid (CAS 2091263-77-1)
- 3,3-difluorocyclobutane-1-carboxamide (CAS 86770-82-3)
- 3,3-Difluorocyclobutane-1-carboximidamide (CAS 1780452-01-8)
- 3,3-difluorocyclobutane-1-thiol (CAS 2228833-09-6)
- (3,3-difluorocyclobutane-1,1-diyl)dimethanamine (CAS 1446422-58-7)
- 3,3-Difluorocyclobutane-1-carbaldehyde (CAS 1246765-49-0)
Recommended Standards
- 3,3-Difluorocyclobutanecarboxylic acid (CAS 107496-54-8)
- 2-(2,2-difluorocyclopropyl)acetic acid (CAS 123131-67-9)
- 4645-32-3 Dimethyl vinylphosphonate Vinylphosphonic acid diMethyl ester, Min. 90% (CAS 4645-32-3)
- 2,2-Difluoro-1-methylcyclopropanecarboxylic Acid (CAS 128073-33-6)
- 7-Methyl-2,3-dihydrobenzo[b][1,4]dioxine-6-carboxylic acid (CAS 924871-41-0)
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- 3-Fluoro-4-(4-methoxyphenyl)pyridine (CAS 1610038-15-7)
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- 3-Oxo-3-(1,3-thiazol-2-yl)propanal (CAS 942223-94-1)
- 1-(4-(4-Hydroxybutyl)phenyl)ethan-1-one (CAS 100256-34-6)
- Semaglutide impurity 248 (CAS CATO-C4X-2226248)
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