5-ethyl-1-[3-(trifluoromethyl)phenyl]-1H-pyrazole-4-carboxylic acid CAS 1152881-59-8
| CAS No. | 1152881-59-8 |
| Molecular Formula | C13H11F3N2O2 |
| Molecular Weight | 284.23 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 5-ethyl-1-[3-(trifluoromethyl)phenyl]-1H-pyrazole-4-carboxylic acid (C13H11F3N2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
5-ethyl-1-[3-(trifluoromethyl)phenyl]-1H-pyrazole-4-carboxylic acid (CAS 1152881-59-8) is a high-purity analytical reference standard with the molecular formula C13H11F3N2O2 and a molecular weight of 284.23 g/mol.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 5-ethyl-1-[3-(trifluoromethyl)phenyl]-1H-pyrazole-4-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H11F3N2O2 |
| Molecular Weight | 284.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related ethyl Standards
- 3-{[5-methyl-3-(trifluoromethyl)-1h-pyrazol-1-yl]methyl}benzoic acid (CAS 1006348-88-4)
- 3-((5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)methoxy)benzaldehyde (CAS 1006460-23-6)
- Ethyl 5-[4-(trifluoromethyl)phenyl]-1h-pyrazole-4-carboxylate (CAS 1017785-30-6)
- ethyl 1-[2-(trifluoromethyl)phenyl]-1H-pyrazole-3-carboxylate (CAS 1461708-18-8)
- 5-ethyl-1-[4-(trifluoromethyl)phenyl]-1H-pyrazole-4-carboxylic acid (CAS 1466051-04-6)
- 2-[(3-Trifluoromethyl)phenyl]-4,6-dimethoxypyrimidine (CAS 402497-49-8)
- 3-(5-(2-(Trifluoromethyl)phenyl)furan-2-yl)propanoic acid (CAS 853310-21-1)
- Ethyl 3-(4-(trifluoromethyl)phenyl)-1H-pyrazole-5-carboxylate (CAS 639784-60-4)
Recommended Standards
- Ethyl 1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate (CAS 112055-34-2)
- 6-Nitro-2-(4-nitrophenyl)imidazo[1,2-a]pyridine (CAS 118000-57-0)
- 1,3-Dimethyl-5-(3-(trifluoromethyl)phenoxy)-1H-pyrazole-4-carbaldehyde (CAS 109925-28-2)
- 1-(4-Amino-3,5-dichloro-phenyl)-2-tert-butyl-d9-amino-ethanone (CAS 129138-59-6)
- 2,3,4,5-Tetrahydropyridine-3-carbonitrile (CAS 140438-51-3)
- 4-(Boc-amino)-1-(trifluoromethyl)cyclohexanol (CAS 1251923-37-1)
- 4-Cyclohexyl-6,7-dimethyl-1,4-dihydroquinazoline-8-carbonitrile (CAS 89638-33-5)
- 6,7-Dimethoxy-5-methyl-2-(methyl(3-nitrobenzyl)amino)quinazolin-4(3H)-one (CAS 894788-72-8)
- 6,8-Difluoro-4-methoxyquinoline-2-carboxylic acid (CAS 1338651-82-3)
- DL-Epinephrine ß-D-Glucuronide (CAS 54964-61-3)
- 4-Chloro-2-(3-ethyl-1,2,4-oxadiazol-5-yl)aniline (CAS 1040345-45-6)
- methyl 3-(dimethylamino)-2-methyl-2-(methylamino)propanoate (CAS 1247638-96-5)
- Darunavir Impurity 15 (CAS 192800-79-6)
- Semaglutide impurity 199 (CAS CATO-C4X-2226199)
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