6-Bromo-8-chloroquinolin-4(1H)-one CAS 1153084-25-3
| CAS No. | 1153084-25-3 |
| Molecular Formula | C9H5BrClNO |
| Molecular Weight | 258.50 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 6-Bromo-8-chloroquinolin-4(1H)-one.
6-Bromo-8-chloroquinolin-4(1H)-one (CAS 1153084-25-3), molecular formula C9H5BrClNO and molecular weight 258.50 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine/bromine substitution, 6-Bromo-8-chloroquinolin-4(1H)-one is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 258.50 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 6-Bromo-8-chloroquinolin-4(1H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H5BrClNO |
| Molecular Weight | 258.50 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 1 |
Related Bromo Standards
- 3-Bromo-7-chloroquinolin-6-ol (CAS 1009811-89-5)
- 4-Bromo-7-chloroisoquinolin-1(2H)-one (CAS 1028252-13-2)
- 6-Bromo-7-chloro-1(2H)-isoquinolinone (CAS 1036712-57-8)
- 6-Bromo-3-chloroquinoxalin-2-amine (CAS 1083181-47-8)
- 7-Bromo-5-chloro-1H-indole-3-carbaldehyde (CAS 1100217-75-1)
- 7-Bromo-2-chloroquinazolin-4-amine (CAS 1107695-08-8)
- 5-Bromo-2-chloroquinazolin-4-amine (CAS 1107695-10-2)
- 4-Bromo-6-chloro-1H-indole-3-carbaldehyde (CAS 115666-32-5)
Recommended Standards
- 5-Bromo-4-chloro-1H-indole-3-carbaldehyde (CAS 115666-39-2)
- 3-Bromo-6-chloroquinolin-2(1H)-one (CAS 1197340-22-9)
- 7-Bromo-3-chloroquinolin-4-ol (CAS 1203579-13-8)
- 5-(4-Bromophenyl)-2-chlorooxazole (CAS 1060816-28-5)
- 2-[(1-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}-2-methylpropan-2-yl)sulfanyl]-1-(4-chlorophenyl)ethan-1-one (CAS 400081-16-5)
- 3-(2-Acetamidophenyl)-1-methyl-2-oxopyrrolidin-3-yl acetate (CAS 62209-21-6)
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- 2-(3,5-Dimethoxyphenyl)-2-(3-methylpiperidin-1-yl)ethanamine (CAS 1019119-76-6)
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- H-γ-Glu-4-Abz-OH (CAS 2643-70-1)
- 1-(4-Aminophenyl)-2-(methylsulfonyl)propan-1-one (CAS 1565984-81-7)
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- (S)-1-(Cyclopropylmethyl)pyrrolidin-3-amine dihydrochloride (CAS 1286208-85-2)
- Des-Ala21-Tirzepatide (CAS CATO-CPTD788952)
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