2-(4-Bromothiophen-2-yl)-4-chloro-6-methylpyrimidine CAS 1153411-17-6
| CAS No. | 1153411-17-6 |
| Molecular Formula | C9H6BrClN2S |
| Molecular Weight | 289.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2-(4-Bromothiophen-2-yl)-4-chloro-6-methylpyrimidine (C9H6BrClN2S) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, chlorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
2-(4-Bromothiophen-2-yl)-4-chloro-6-methylpyrimidine (CAS 1153411-17-6) is a high-purity analytical reference standard with the molecular formula C9H6BrClN2S and a molecular weight of 289.58 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H6BrClN2S |
| Molecular Weight | 289.58 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Bromothiophen Standards
- 2-(5-Bromothiophen-2-yl)-4-chloro-6-methylpyrimidine (CAS 1155155-56-8)
- (1-((5-Bromothiophen-2-yl)methyl)piperidin-3-yl)methanamine (CAS 1019457-89-6)
- n-((4-Bromothiophen-2-yl)methyl)-1-methylpiperidin-4-amine (CAS 1096850-13-3)
- N-((5-bromothiophen-2-yl)methyl)-1-methylpiperidin-4-amine (CAS 1096878-42-0)
- N-(1-(5-bromothiophen-2-yl)ethyl)-1-methylpyrrolidin-3-amine (CAS 1248220-68-9)
- 1-((5-Bromothiophen-2-yl)methyl)-4-ethylpiperazine (CAS 414876-29-2)
- 1-(4-Bromothiophen-2-yl)-N-(thiazol-5-ylmethyl)methanamine (CAS 1344301-95-6)
- (3-Bromothiophen-2-yl)(5-methylthiophen-2-yl)methanol (CAS 1344017-76-0)
Recommended Standards
- 6-Bromo-4-chloro-2-(methylsulfanyl)quinazoline (CAS 1003043-76-2)
- 934986-60-4 2,4,6-Trichlorophenyl 1-ethanesulfonate MFCD12498727 (CAS 934986-60-4)
- 3-[(4-Bromophenyl)methyl]-5-chloro-1,2,4-thiadiazole (CAS 1221342-57-9)
- Des-(4-(4-fluorobenzoyl)) 1-(3-Bromopropyl) Milenperone (CAS 63388-35-2)
- (1R,2S,3S,5S)-3-(4-Iodophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid (CAS 141807-58-1)
- 2-(5-Chloro-1h-benzo[d]imidazol-2-yl)cyclohexane-1-carboxylic acid (CAS 1152551-69-3)
- Thieno[3,2-c]pyridin-6-amine (CAS 1378751-30-4)
- Fmoc-(1S,2S)-2-aminocyclohexane carboxylic acid (CAS 312965-07-4)
- methyl 3-methoxyquinoline-6-carboxylate (CAS 1051316-27-8)
- Olopatadine (CAS 113806-05-6)
- Ethyl 3-Phenoxybenzoate (CAS 60677-14-7)
- 2-Fluoro-4-(methylsulfonyl)aniline (CAS 832755-13-2)
- (2-Chlorothiazol-5-yl)methyl 3-methylbenzoate (CAS 341967-65-5)
- Semaglutide Impurity 16 (CAS CATO-C4X-222616)
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