7-bromo-5-chloro-2,3-dihydro-1-benzofuran-3-one CAS 1153445-36-3
| CAS No. | 1153445-36-3 |
| Molecular Formula | C8H4BrClO2 |
| Molecular Weight | 247.47 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 7-bromo-5-chloro-2,3-dihydro-1-benzofuran-3-one.
7-bromo-5-chloro-2,3-dihydro-1-benzofuran-3-one (CAS 1153445-36-3) is a high-purity analytical reference standard with the molecular formula C8H4BrClO2 and a molecular weight of 247.47 g/mol.
The molecular framework of 7-bromo-5-chloro-2,3-dihydro-1-benzofuran-3-one (C8H4BrClO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H4BrClO2 |
| Molecular Weight | 247.47 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl/Br-containing |
Related bromo Standards
- 5-Bromo-7-chloro-2,3-dihydro-1-benzofuran-3-one (CAS 1153450-18-0)
- 2-Bromo-6-chlorobenzofuran-3(2H)-one (CAS 857062-41-0)
- 3-Bromo-6-chloroisobenzofuran-1(3H)-one (CAS 40125-48-2)
- 7-Bromo-5-chloro-1H-benzo[d]imidazol-2-ol (CAS 1035390-48-7)
- 6-Bromo-5-chloro-[1,2,4]triazolo[1,5-a]pyridin-2-amine (CAS 1124382-99-5)
- 3-Bromo-6-chloro-1H-pyrrolo[2,3-b]pyridin-4-ol (CAS 1190314-89-6)
- 4-Bromo-5-chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one (CAS 1190318-30-9)
- 7-Bromo-6-chloro-5-aza-2-oxindole (CAS 1190319-75-5)
Recommended Standards
- 2-(Dimethyl(6-methylhept-1-en-4-yl)silyl)pyridine (CAS 358782-88-4)
- 1,2-Difluoro-3-(trichloromethoxy)benzene (CAS 158178-39-3)
- n-Hexadecyl-2,2,16,16,16-d5 Alcohol (CAS 1219799-18-4)
- 1,4-Difluoro-2-(trichloromethoxy)benzene 1404194-69-9 (CAS 1404194-69-9)
- 3-(5-Chloro-2-phenoxyphenyl)-1-methylpyrrolidine-2,4-dione, 97% (CAS 1162120-35-5)
- 2,5-Dichloro-4-methoxyphenylboronic acid (CAS 1612184-34-5)
- 1-(4-Bromo-2-chlorophenoxymethyl)-1h-pyrazole-3-carboxylic acid (CAS 1001500-72-6)
- 2-Amino-N-methyl-4-(methylsulfonyl)benzamide (CAS 1201935-75-2)
- 1-Ethoxycyclopropan-1-amine (CAS 63805-75-4)
- 1-(4-Fluorobenzyl)-3-((4-fluorobenzyl)oxy)-N-(furan-2-ylmethyl)-1H-pyrazole-4-carboxamide (CAS 1013755-46-8)
- 4-(Diethylamino)-3-iodobenzoic acid (CAS 1131588-22-1)
- N-(2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)cyclohexanamine (CAS 2377612-04-7)
- (R)-2-(1-aminoethyl)benzonitrile (CAS 1213885-82-5)
- Semaglutide impurity 266 (CAS CATO-C4X-2226266)
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