(R)-5-oxo-2-(trifluoromethyl)pyrrolidine-2-carboxylic acid CAS 1153474-68-0
| CAS No. | 1153474-68-0 |
| Molecular Formula | C6H6F3NO3 |
| Molecular Weight | 197.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (R)-5-oxo-2-(trifluoromethyl)pyrrolidine-2-carboxylic acid.
CATO supplies (R)-5-oxo-2-(trifluoromethyl)pyrrolidine-2-carboxylic acid (CAS 1153474-68-0), a certified reference material (molecular formula C6H6F3NO3, MW 197.11 g/mol) for analytical method development and quality control.
(R)-5-oxo-2-(trifluoromethyl)pyrrolidine-2-carboxylic acid (C6H6F3NO3) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (R)-5-oxo-2-(trifluoromethyl)pyrrolidine-2-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H6F3NO3 |
| Molecular Weight | 197.11 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- (S)-5-oxo-2-(trifluoromethyl)pyrrolidine-2-carboxylic acid (CAS 1153474-63-5)
- Pentafluoro-N-methylaniline (CAS 1201-02-1)
- 4-Amino-2,5-difluorobenzotrifluoride (CAS 114973-22-7)
- 3,5-Difluoro-4-(trifluoromethyl)aniline (CAS 123950-44-7)
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- (2R,4R)-4-fluoropyrrolidine-2-carbonitrile (CAS 1637365-35-5)
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