1-(3,4-Difluorophenoxy)propan-2-one CAS 1153999-83-7
| CAS No. | 1153999-83-7 |
| Molecular Formula | C9H8F2O2 |
| Molecular Weight | 186.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 1-(3,4-Difluorophenoxy)propan-2-one (C9H8F2O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
1-(3,4-Difluorophenoxy)propan-2-one (CAS 1153999-83-7), molecular formula C9H8F2O2 and molecular weight 186.16 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-(3,4-Difluorophenoxy)propan-2-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H8F2O2 |
| Molecular Weight | 186.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
Related Difluorophenoxy Standards
- (S)-2-((3,4-Difluorophenoxy)methyl)oxirane (CAS 144574-27-6)
- 2-((2,4-Difluorophenoxy)methyl)oxirane (CAS 169286-61-7)
- 2-(2,4-difluorophenoxy)acetamide (CAS 399-43-9)
- 3-(2,3-Difluorophenoxy)azetidine (CAS 1211876-03-7)
- 3-(2,6-Difluorophenoxy)azetidine (CAS 1211876-06-0)
- 3-(2,5-Difluorophenoxy)azetidine (CAS 1263378-42-2)
- 3-(3,5-Difluorophenoxy)azetidine (CAS 1263378-82-0)
- 3-(2,4-Difluorophenoxy)azetidine (CAS 954225-05-9)
Recommended Standards
- 2,2-Difluoro-1-(4-methoxyphenyl)ethanone (CAS 114829-07-1)
- Diallyl dicarbonate (CAS 115491-93-5)
- 2-[4-(difluoromethoxy)phenyl]oxirane (CAS 1094302-44-9)
- 1-(3,4-Difluorophenyl)-2-methoxyethan-1-one (CAS 1157136-76-9)
- 2-{4-[(Methylamino)methyl]phenoxy}benzonitrile hydrochloride (CAS 1185294-77-2)
- 2-(5-(2-Methylcyclopropyl)furan-2-yl)acetonitrile (CAS 1250100-31-2)
- 1,2,4,7,8-Pentabromodibenzo-p-dioxin (CAS 109333-35-9)
- 4-{[4-(dimethylamino)phenyl]methylidene}-1,2,3,4-tetrahydroacridine-9-carboxylic acid (CAS 379728-16-2)
- N1,N4-Di(buta-2,3-dien-1-yl)butane-1,4-diamine dHCl (CAS 93565-01-6)
- 4,5-Dihydro-3H-benzo[c]azepine (CAS 23758-95-4)
- 3-Iodo-2-phenyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole (CAS 1338582-28-7)
- 7-Chloro-4,4-difluoroisoquinoline-1,3(2H,4H)-dione (CAS 1393726-80-1)
- 1-{[4-(4-Nitrophenyl)phenyl]carbonyl}piperidine (CAS 1355246-86-4)
- Semaglutide Impurity 4 (CAS CATO-C4X-22264)
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