4-[(2-chloropyridin-3-yl)sulfonyl]thiomorpholine CAS 1156386-14-9
| CAS No. | 1156386-14-9 |
| Molecular Formula | C9H11ClN2O2S2 |
| Molecular Weight | 278.78 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-[(2-chloropyridin-3-yl)sulfonyl]thiomorpholine (CAS 1156386-14-9) is a high-purity analytical reference standard with the molecular formula C9H11ClN2O2S2 and a molecular weight of 278.78 g/mol.
The molecular framework of 4-[(2-chloropyridin-3-yl)sulfonyl]thiomorpholine (C9H11ClN2O2S2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-[(2-chloropyridin-3-yl)sulfonyl]thiomorpholine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H11ClN2O2S2 |
| Molecular Weight | 278.78 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 2 |
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Recommended Standards
- Venetoclax Impurity 12 (CAS 1228780-49-1)
- 2-(4-Chlorobenzyl)-2,8-diazaspiro[4.5]decan-3-one (CAS 1258000-09-7)
- Rosuvastatin Impurity 96 (CAS 521974-00-5)
- N-(2-(5-(tert-Butyl)-1H-1,2,4-triazol-3-yl)ethyl)-4-chloroaniline (CAS 1279203-88-1)
- 7-Amino-2,2-dimethyl-2h-pyrido[3,2-b][1,4]oxazin-3(4h)-one (CAS 575473-97-1)
- (4-Benzhydrylpiperazin-1-yl)(2-(methylthio)pyridin-3-yl)methanone (CAS 852851-09-3)
- 5-bromo-3-(4-methylbenzoyl)thiophen-2-amine (CAS 1803609-31-5)
- (2,5-Dicyclopropyl-1,3-oxazol-4-yl)methanamine (CAS 1353496-64-6)
- 5-Sulfamoyl-2-[3-(trifluoromethyl)phenyl]benzoic acid (CAS 926222-83-5)
- Dichlorodimethyl-d (CAS 80311-36-0)
- Tetrahydropyran-4-sulfonyl Chloride (CAS 338453-21-7)
- 1H-Purin-6(9H)-one- (CAS 1246820-04-1)
- 2-(1,1,2,3,3,3-Hexafluoropropoxy)aniline (CAS 41242-02-8)
- Semaglutide Impurity 16 (CAS CATO-C4X-222616)
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