1,3-Bis(1-hydroxy-2,2,2-trichloroethyl)urea CAS 116-52-9
| CAS No. | 116-52-9 |
| Molecular Formula | C5H6Cl6N2O3 |
| Molecular Weight | 354.83 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
1,3-Bis(1-hydroxy-2,2,2-trichloroethyl)urea (CAS 116-52-9), molecular formula C5H6Cl6N2O3 and molecular weight 354.83 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, 1,3-Bis(1-hydroxy-2,2,2-trichloroethyl)urea is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 354.83 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H6Cl6N2O3 |
| Molecular Weight | 354.83 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Bis Standards
- 4-Hydroxy-1H-imidazo[4,5-c]pyridin-6(5H)-one (CAS 91160-07-5)
- 1-Hydroxy-4-((4-methoxyphenyl)thio)anthracene-9,10-dione (CAS 16673-01-1)
- 4-Hydroxy-3-(((4-iodophenyl)imino)methyl)-6-methyl-2H-pyran-2-one (CAS 380328-14-3)
- N-(4-Hydroxy-2-oxo-1-phenyl-1,2,5,6,7,8-hexahydroquinolin-3-yl)hexanamide (CAS 893601-94-0)
- 17alpha-Hydroxy-yohimban-16alpha-carboxylic Acid Methyl Ester (CAS 146-48-5)
- Methyl 4-(2-((2-hydroxy-2-methyl-4-(methylthio)butyl)amino)-2-oxoacetamido)benzoate (CAS 1396807-03-6)
- 2-Hydroxy-2-methyl-N-[6-(tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalen-2-yl]propanamide (CAS 2377607-33-3)
- 9-((7-Hydroxy-3,7-dimethylocta-2,5-dien-1-yl)oxy)-7H-furo[3,2-g]chromen-7-one (CAS 144398-34-5)
Recommended Standards
- Desloratadine Impurity 28 (CAS CATO-C4X-143028)
- 3-Chloro-N-(2-methoxyethyl)-2-methyl-N-(pyridin-4-ylmethyl)benzenesulfonamide (CAS 1286718-29-3)
- N,N'-((1S,4R)-2-chlorocyclohex-2-ene-1,4-diyl)dibenzamide (CAS 2053651-97-9)
- 2-(4-(3-Chloro-4-methoxyphenyl)-2-(diethylamino)thiazol-5-yl)acetic acid (CAS 1443287-98-6)
- Ethyl 2-cyclopropylthiazole-5-carboxylate (CAS 1369775-72-3)
- 2-(Morpholinomethyl)-1H-benzo[d]imidazol-6-amine (CAS 313518-70-6)
- (S)-2-Methyloxirane-2-carboxylic acid (CAS 162251-64-1)
- 8-Heptadecene (CAS 2579-04-6)
- (Rac)-Benzyl 2-methylpiperazine-1-carboxylate hydrochloride (CAS 1187928-18-2)
- N-Ethylpropylamine (CAS 20193-20-8)
- 1-(2-Methylphenyl)butan-2-one (CAS 26667-68-5)
- 4,4′-Methylenedianiline-2,2′,6,6′,N,N,N′,N′-d8 (CAS 1219795-26-2)
- 3-(Hydroxymethyl)-1-(((5-nitrofuran-2-yl)methylene)amino)imidazolidine-2,4-dione (CAS 1088-92-2)
- D-Ala18-Tirzepatide (CAS CATO-CPTD788916)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com