tert-Butyl spiro[3,4-dihydro-2H-isoquinoline-1,4'-piperidine]-1'-carboxylate CAS 1160247-65-3
| CAS No. | 1160247-65-3 |
| Molecular Formula | C18H26N2O2 |
| Molecular Weight | 302.41 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies tert-Butyl spiro[3,4-dihydro-2H-isoquinoline-1,4'-piperidine]-1'-carboxylate (CAS 1160247-65-3), a certified reference material (molecular formula C18H26N2O2, MW 302.41 g/mol) for analytical method development and quality control.
The molecular framework of tert-Butyl spiro[3,4-dihydro-2H-isoquinoline-1,4'-piperidine]-1'-carboxylate (C18H26N2O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), tert-Butyl spiro[3,4-dihydro-2H-isoquinoline-1,4'-piperidine]-1'-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H26N2O2 |
| Molecular Weight | 302.41 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Nitrogen Atoms | 2 |
Recommended Standards
- 1,6-Diazaspiro[3.4]octane-1-carboxylic acid, 6-(phenylmethyl)-, 1,1-dimethylethyl ester (CAS 1148044-30-7)
- tert-Butyl 1',4'-dihydro-2'H-spiro[piperidine-4,3'-quinoline]-1-carboxylate (CAS 1160247-77-7)
- Tert-butyl 5-methylspiro[indoline-3,4'-piperidine]-1'-carboxylate (CAS 1129411-47-7)
- Tert-butyl 3-(indolin-3-yl)piperidine-1-carboxylate (CAS 1160248-25-8)
- 1-(4,6-Dimethylpyrimidin-2-yl)-3-(2-methoxyphenyl)guanidine (CAS 304868-09-5)
- (E)-Methyl 4-(4-chlorophenyl)but-2-enoate (CAS 1250907-53-9)
- 1-(3-Carbamoyl-4-nitrophenyl)piperidine-4-carboxylic acid (CAS 439095-54-2)
- 3-(Dimethylamino)-1-(1-ethyl-1h-pyrazol-4-yl)prop-2-en-1-one (CAS 1006460-81-6)
- N-(5-(tert-Butyl)-1,3,4-thiadiazol-2-yl)tetrahydrofuran-2-carboxamide (CAS 600159-96-4)
- 3-Fluoro-5-(trifluoromethyl)pyridine-2-acetonitrile (CAS 1227592-18-8)
- Methyl (3S)-3-amino-3-(3-chlorophenyl)propanoate (CAS 309757-83-3)
- 6-Aminoisoquinoline (CAS 23687-26-5)
- 2-((4-(4-Ethoxyphenyl)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)-1-(4-fluorophenyl)ethanone (CAS 477331-51-4)
- Semaglutide impurity 28 (CAS CATO-C4X-222628)
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