7-Chloro-2-(3,4-dimethoxyphenyl)-8-methylquinoline-4-carbonyl chloride CAS 1160256-52-9
| CAS No. | 1160256-52-9 |
| Molecular Formula | C19H15Cl2NO3 |
| Molecular Weight | 376.23 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 7-Chloro-2-(3,4-dimethoxyphenyl)-8-methylquinoline-4-carbonyl chloride.
7-Chloro-2-(3,4-dimethoxyphenyl)-8-methylquinoline-4-carbonyl chloride (CAS 1160256-52-9), molecular formula C19H15Cl2NO3 and molecular weight 376.23 g/mol, is a CATO reference standard with documented purity and traceability.
7-Chloro-2-(3,4-dimethoxyphenyl)-8-methylquinoline-4-carbonyl chloride (C19H15Cl2NO3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H15Cl2NO3 |
| Molecular Weight | 376.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 7-Chloro-2-(2,5-dimethoxyphenyl)-8-methylquinoline-4-carbonyl chloride (CAS 1160256-57-4)
- Ethyl 2-(6-chloro-2-(4-chlorobenzoyl)-1H-indol-3-yl)acetate (CAS 231294-93-2)
- (5-Chloro-1-methyl-3-phenyl-1H-pyrazol-4-yl)methyl (4-chlorophenyl)carbamate (CAS 318248-37-2)
- 5-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)methyl)thiophene-2-sulfonyl chloride (CAS 339010-78-5)
- 2-Chloro-4-(2-chloro-4-nitrostyryl)benzene-1-sulfonyl fluoride (CAS 31368-18-0)
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- 2-Chloro-6-(2-chloro-4-nitrostyryl)benzene-1-sulfonyl fluoride (CAS 31368-21-5)
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Recommended Standards
- 3-(((4-(Trifluoromethoxy)phenyl)sulfonyl)methyl)-5-(trifluoromethyl)-1,2,4-oxadiazole (CAS 1020252-42-9)
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- (2S,4S)-1-(tert-Butoxycarbonyl)-4-(2,4-dichloro-phenoxy)-2-pyrrolidinecarboxylic acid (CAS 1217721-42-0)
- Diethyl 2-[2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl]propanedioate (CAS 55810-48-5)
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- 2-methoxyÂ-1-formylÂmorpholine (CAS 61020-09-5)
- Ethyl 2-[2-(1-phenyl-1H-pyrazole-4-carbonyl)phenoxy]acetate (CAS 93065-69-1)
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