3-(1,3-Dioxolan-2-yl)-1-(4-(trifluoromethyl)phenyl)propan-1-one CAS 116332-53-7
| CAS No. | 116332-53-7 |
| Molecular Formula | C13H13F3O3 |
| Molecular Weight | 274.24 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
3-(1,3-Dioxolan-2-yl)-1-(4-(trifluoromethyl)phenyl)propan-1-one (CAS 116332-53-7) is a high-purity analytical reference standard with the molecular formula C13H13F3O3 and a molecular weight of 274.24 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, 3-(1,3-Dioxolan-2-yl)-1-(4-(trifluoromethyl)phenyl)propan-1-one is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 274.24 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 3-(1,3-Dioxolan-2-yl)-1-(4-(trifluoromethyl)phenyl)propan-1-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H13F3O3 |
| Molecular Weight | 274.24 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
Related Dioxolan Standards
- 3-(1,3-Dioxolan-2-yl)-1-(3-(trifluoromethyl)phenyl)propan-1-one (CAS 842123-89-1)
- (5-(1,3-Dioxolan-2-yl)thiophen-2-yl)(o-tolyl)methanone (CAS 898773-17-6)
- (5-(1,3-Dioxolan-2-yl)thiophen-2-yl)(p-tolyl)methanone (CAS 898773-23-4)
- 1-[5-(4-[1,3]Dioxolan-2-yl-phenyl)-thiophen-2-yl]-ethanone (CAS 893741-67-8)
- 1-{5-[3-(1,3-Dioxolan-2-yl)phenyl]-2-thienyl}ethanone (CAS 893741-71-4)
- 5-(1,3-Dioxolan-2-yl)-2-(3-methylbenzoyl)thiophene (CAS 898773-20-1)
- 2-(3-(1,3-Dioxolan-2-yl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1257648-34-2)
- (2-Oxo-1,3-dioxolan-4-yl)methyl 4-methylbenzenesulfonate (CAS 949895-84-5)
Recommended Standards
- 1-(4-Nitro-phenyl)-4-trifluoromethyl-piperidine (CAS 1159984-44-7)
- 1-Ethyl-N-(5-(isoxazol-5-yl)-1,3,4-oxadiazol-2-yl)-1H-pyrazole-3-carboxamide (CAS 1170141-56-6)
- 3-Bromobenzylmagnesium bromide solution (CAS 107549-22-4)
- 2-(Cyclopropylamino)-N-(4-(trifluoromethoxy)phenyl)acetamide (CAS 1183768-44-6)
- N-[2-(3,5-Dimethylphenoxy)ethyl]-1-phenyl-1-ethanamine (CAS 1040690-03-6)
- Methyl 8-isopropyl-4-phenylquinoline-2-carboxylate (CAS 351419-73-3)
- 2-(2,5-Difluorophenyl)-2-morpholinoethan-1-amine (CAS 1096350-86-5)
- aluminum sulfide (CAS 1302-81-4)
- 1-(3-Isopropoxypropyl)-1h-pyrazol-3-amine (CAS 1339422-72-8)
- Doxaminol (CAS 55286-56-1)
- (2,2-Dibromovinyl)cyclohexane (CAS 60754-49-6)
- 4-Ethyl-5-{thieno[2,3-b]quinolin-2-yl}-4H-1,2,4-triazole-3-thiol (CAS 478260-35-4)
- N-(3,5-di-tert-butylphenyl)benzamide (CAS 205651-75-8)
- Semaglutide impurity 92 (CAS CATO-C4X-222692)
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