2-chloro-8-methylquinazoline CAS 1169786-94-0
| CAS No. | 1169786-94-0 |
| Molecular Formula | C9H17ClN2 |
| Molecular Weight | 188.70 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-chloro-8-methylquinazoline.
2-chloro-8-methylquinazoline (CAS 1169786-94-0) is a high-purity analytical reference standard with the molecular formula C9H17ClN2 and a molecular weight of 188.70 g/mol.
The molecular framework of 2-chloro-8-methylquinazoline (C9H17ClN2) is characterized by a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H17ClN2 |
| Molecular Weight | 188.70 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
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- 3-cyanocyclobutane-1-sulfonyl chloride (CAS 1882089-34-0)
- methyl 6-fluoro-3-methyl-2-oxo-1,3-benzoxazole-4-carboxylate (CAS 2387597-46-6)
- 1-(4-Fluorobenzyl)-5-oxo-N-(4-oxo-4H-chromen-2-yl)pyrrolidine-2-carboxamide (CAS 59749-50-7)
- 1-(3,6-Dibromopyrazin-2-yl)ethan-1-one (CAS 1447607-04-6)
- Menaquinone 7 (CAS 2124-57-4)
- Des-Phe22-Tirzepatide (CAS CATO-CPTD788951)
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