3-Methyl-1-(2,2,3,3-tetrafluoropropyl)-1h-pyrazole CAS 1169988-14-0
| CAS No. | 1169988-14-0 |
| Molecular Formula | C7H8F4N2 |
| Molecular Weight | 196.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 3-Methyl-1-(2,2,3,3-tetrafluoropropyl)-1h-pyrazole is closely related to a nitrile group, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
3-Methyl-1-(2,2,3,3-tetrafluoropropyl)-1h-pyrazole (CAS 1169988-14-0), molecular formula C7H8F4N2 and molecular weight 196.15 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 3-Methyl-1-(2,2,3,3-tetrafluoropropyl)-1h-pyrazole (C7H8F4N2) is characterized by a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H8F4N2 |
| Molecular Weight | 196.15 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Methyl Standards
- 1-(2,2,3,3-Tetrafluoropropyl)-1h-pyrazol-4-amine (CAS 1006486-95-8)
- 1-(2,2,3,3-Tetrafluoropropyl)piperazine (CAS 23476-98-4)
- 2,2,3,3-Tetrafluoropropyl2-fluoroacrylate (CAS 96250-37-2)
- Ethyl (2,2,3,3-tetrafluoropropyl) carbonate (CAS 277332-97-5)
- 2,2,3,3-Tetrafluoropropyl propanoate (CAS 2062-06-8)
- 2,2,3,3-Tetrafluoropropyl acrylate (CAS 7383-71-3)
- 2,2,3,3-Tetrafluoropropyl 2,2-difluoroacetate (CAS 1365808-08-7)
- 3-Methyl-1-(2,2,3,3-tetrafluoropropyl)-1h-pyrazol-4-amine (CAS 1006487-02-0)
Recommended Standards
- 3,5-difluorobenzene-1-sulfonyl fluoride (CAS 115650-77-6)
- 2-(Trifluoromethyl)thiazole-4-carboxamide (CAS 1180526-74-2)
- 3,4-Difluoro-benzenesulfonyl fluoride (CAS 115561-01-8)
- 6-Fluoro-1-(fluoromethyl)-1H-benzo[d]imidazole-2-carbaldehyde (CAS 118469-18-4)
- ((Dioctylstannanediyl)bis(sulfanediyl))bis(ethane-2,1-diyl) didodecanoate (CAS 28570-25-4)
- Methyl 3-amino-5-chloro-4-methoxybenzoate (CAS 40256-83-5)
- Ac-D-Lys-OH (CAS 58840-79-2)
- Ethyl 2-cyano-2-cyclododecylideneacetate (CAS 184866-86-2)
- 3-Cyclopropoxy-2-(methylsulfonamido)isonicotinic acid (CAS 1243318-50-4)
- (S)-2-Amino-3-(1H-imidazol-5-yl)propanoic acid compound with acetic acid (1:1) (CAS 71173-63-2)
- 3-Methoxy-4-(oxetan-3-yloxy)aniline (CAS 1349717-19-6)
- Methyl 2-(methoxymethyl)isonicotinate (CAS 148258-24-6)
- AZD3965 (CAS 1448671-31-5)
- Palmitoyl Tripeptide -5 · 2 TFA (CAS 623172-56-5)
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