1-[4-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-6-(trifluoromethyl)pyrimidin-2-yl]piperidin-4-amine CAS 1170525-72-0
| CAS No. | 1170525-72-0 |
| Molecular Formula | C16H21F3N6 |
| Molecular Weight | 354.37 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 1-[4-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-6-(trifluoromethyl)pyrimidin-2-yl]piperidin-4-amine is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
1-[4-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-6-(trifluoromethyl)pyrimidin-2-yl]piperidin-4-amine (CAS 1170525-72-0), molecular formula C16H21F3N6 and molecular weight 354.37 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 1-[4-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-6-(trifluoromethyl)pyrimidin-2-yl]piperidin-4-amine (C16H21F3N6) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 1-[4-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-6-(trifluoromethyl)pyrimidin-2-yl]piperidin-4-amine under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H21F3N6 |
| Molecular Weight | 354.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 6 |
Recommended Standards
- tert-Butyl 4-[(2-fluoro-4-nitrophenoxy)methyl]piperidine-1-carboxylate (CAS 1000051-97-7)
- 1-(4-(1-Ethyl-5-methyl-1h-pyrazol-4-yl)-6-(trifluoromethyl)pyrimidin-2-yl)piperidin-4-amine (CAS 1172353-24-0)
- Fmoc-D-Asn-OH (CAS 108321-39-7)
- tert-Butyl 4-[(2-fluoro-6-nitrophenoxy)methyl]piperidine-1-carboxylate (CAS 1286264-91-2)
- tert-butyl N-[(1S,2R)-2-hydroxycyclohexyl]carbamate (CAS 214679-17-1)
- (1-amino-2-methylpropan-2-yl)(methyl)amine dihydrochloride (CAS 1423024-99-0)
- 1-[(3,4-dimethoxyphenyl)methyl]-4-methyl-1H-pyrazol-5-amine (CAS 1152526-79-8)
- spiro[1H-pyrrolo[2,3-b]pyridine-3,1'-cyclopropane]-2-one (CAS 1416438-78-2)
- Quinoxaline-5,6,7,8-d4 (CAS 64252-08-0)
- 6-Methoxyhexan-1-ol (CAS 57021-65-5)
- 2-((2,6-Dimethylpyrimidin-4-yl)amino)-1-phenylethan-1-ol (CAS 1179509-96-6)
- 2-[[[1,4-Dihydro-4-oxo-5-(2-thienyl)thieno[2,3-d]pyrimidin-2-yl]methyl]thio]acetic acid (CAS 743453-36-3)
- (5-Amino-2-pyrrolidin-1-yl-phenyl)-pyrrolidin-1-yl-methanone (CAS 878658-52-7)
- Liraglutide Sodium Salt (CAS 204656-20-2（free base）)
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