1-(2-Fluorophenyl)-5-(1H-pyrrol-1-yl)-1H-pyrazole-4-carboxylic acid CAS 1172017-52-5
| CAS No. | 1172017-52-5 |
| Molecular Formula | C14H10FN3O2 |
| Molecular Weight | 271.25 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 1-(2-Fluorophenyl)-5-(1H-pyrrol-1-yl)-1H-pyrazole-4-carboxylic acid (C14H10FN3O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies 1-(2-Fluorophenyl)-5-(1H-pyrrol-1-yl)-1H-pyrazole-4-carboxylic acid (CAS 1172017-52-5), a certified reference material (molecular formula C14H10FN3O2, MW 271.25 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H10FN3O2 |
| Molecular Weight | 271.25 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Fluorophenyl Standards
- 1-(2-Fluorophenyl)-6-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid (CAS 1011397-25-3)
- 1-(4-Fluorophenyl)-6-methyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid (CAS 1011397-72-0)
- 1015873-61-6 1-(4-Fluorophenyl)-5-(1H-pyrrol-1-yl)-1H-pyrazole-4-carboxylic acid MFCD09863281 (CAS 1015873-61-6)
- 3-(4-Fluorophenyl)-5-(6-hydrazinylpyridin-3-yl)-1,2,4-oxadiazole (CAS 1325304-32-2)
- 3-(4-Fluorophenyl)-5-(2-hydrazinylpyridin-3-yl)-1,2,4-oxadiazole (CAS 1351398-77-0)
- 4-(4-Fluorophenyl)-1-methyl-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid (CAS 1354704-92-9)
- 3-[3-(3-Fluorophenyl)-1,2,4-oxadiazol-5-yl]-2-hydrazinylpyridine (CAS 1370598-66-5)
- 5-(4-Fluorophenyl)-3-methylpyrazolo[1,5-a]pyrimidine-7-carboxylic acid (CAS 1443279-63-7)
Recommended Standards
- 2-Fluoro-N-(6-methylisoxazolo[5,4-b]pyridin-3-yl)benzamide (CAS 1105206-86-7)
- 1-(4-Fluoro-3-(trifluoromethyl)phenyl)cyclohexanecarbonitrile (CAS 1260807-20-2)
- 524684-52-4 A9C8MNF7CA Prinaberel [USAN:INN] 5-Benzoxazolol, 7-ethenyl-2-(3-fluoro-4-hydroxyphenyl)- ERB-041 ERB 041 Prinaberel 7-Ethenyl-2-(3-fluoro-4-hydroxyphenyl)benzoxazol-5-ol UNII-A9C8MNF7CA (CAS 524684-52-4)
- N-(5-Acetyl-2,3-dihydro-1H-inden-2-yl)-2,2,2-trifluoroacetamide, 97% (CAS 601487-87-0)
- 2-(1,4-Dithiaspiro[4.5]decan-6-yl)isonicotinic acid (CAS 1706461-46-2)
- 2-Propen-1-amine, N-methyl-N-2-propen-1-yl-, acetate hydrochloride, compd. with 2-(chloromethyl)oxirane homopolymer (CAS 76649-33-7)
- 2-Ethoxy-3,5-diiodobenzaldehyde (CAS 708272-98-4)
- 1-Methylquinolin-2(1H)-imine (CAS 18029-51-1)
- 2-Isopropyl-1H-benzo[d]imidazol-5-ol (CAS 470715-52-7)
- 2-Amino-3-(3-methoxy-5-methylphenyl)propanoic acid (CAS 603106-30-5)
- 6-(Chloromethyl)benzo[d]isoxazol-3(2H)-one (CAS 947408-97-1)
- (4-(Thiazol-2-yl)furan-2-yl)boronic acid (CAS 2096336-38-6)
- Ethyl (3E)-3-(acetylhydrazono)-2-chlorobutanoate (CAS 66552-43-0)
- Semaglutide impurity 331 (CAS CATO-C4X-2226231)
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