1'-Methyl-4'-[4-(trifluoromethyl)phenyl]-1'',2,2'',4-tetrahydrodispiro[1-benzopyran-3,3'-pyrrolidine-2',3''-indole]-2'',4-dione CAS 1177520-27-2
| CAS No. | 1177520-27-2 |
| Molecular Formula | C27H21F3N2O3 |
| Molecular Weight | 478.46 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1'-Methyl-4'-[4-(trifluoromethyl)phenyl]-1'',2,2'',4-tetrahydrodispiro[1-benzopyran-3,3'-pyrrolidine-2',3''-indole]-2'',4-dione (CAS 1177520-27-2) is a high-purity analytical reference standard with the molecular formula C27H21F3N2O3 and a molecular weight of 478.46 g/mol.
The molecular framework of 1'-Methyl-4'-[4-(trifluoromethyl)phenyl]-1'',2,2'',4-tetrahydrodispiro[1-benzopyran-3,3'-pyrrolidine-2',3''-indole]-2'',4-dione (C27H21F3N2O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 1'-Methyl-4'-[4-(trifluoromethyl)phenyl]-1'',2,2'',4-tetrahydrodispiro[1-benzopyran-3,3'-pyrrolidine-2',3''-indole]-2'',4-dione meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C27H21F3N2O3 |
| Molecular Weight | 478.46 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Methyl Standards
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Recommended Standards
- MF-766, >98% (HPLC) (CAS 1050656-06-8)
- N-(2-Amino-3,8-dimethylimidazo[4,5-f]quinoxalin-5-yl) 2-Deoxyguanosine (CAS 142038-30-0)
- Z-Asp(ONp)-OBzl (CAS 58238-28-1)
- N2-(Deoxyguanosin-8-yl)-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (CAS 142038-31-1)
- 6-Bromo-2-(1-propyn-1-yl)-3-pyridinamine (CAS 2568470-12-0)
- 4-(5-Bromo-2-methoxyphenyl)butan-2-amine (CAS 1291656-88-6)
- 2,3-Dicyano-5,6-diphenylpyrazine 5,6-Diphenyl-2,3-dicyanopyrazine 5,6-Diphenyl-2,3-pyrazinedicarbonitrile 52197-23-6 NSC 173949 (CAS 52197-23-6)
- 2-(Isopentyloxy)-5-methylbenzaldehyde (CAS 1343000-53-2)
- 1-(4-chlorophenyl)-1H-pyrazol-4-amine (CAS 14044-28-1)
- 4-Cyclopropyl-1-(3,4-dimethylphenyl)-1,6-dihydro-7H-pyrazolo[3,4-d]pyridazin-7-one (CAS 1105197-29-2)
- 2-(3-Hydroxyphenyl)-N-propylacetamide (CAS 1249044-75-4)
- 4-Amino-2-bromoacetophenone (CAS 23442-14-0)
- N-[2-(2,6-dioxo-3-piperidyl)-1-oxo-isoindolin-4-yl]-7-(hydroxyamino)-7-oxo-heptanamide (CAS 2758388-35-9)
- Acetyl-Tau Peptide (273-284) amide trifluoroacetate salt (CAS 1684399-52-7)
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