1-(Chloromethyl)-2-(2,2-difluoroethoxy)benzene CAS 1178363-01-3
| CAS No. | 1178363-01-3 |
| Molecular Formula | C9H9ClF2O |
| Molecular Weight | 206.62 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Structurally, 1-(Chloromethyl)-2-(2,2-difluoroethoxy)benzene (C9H9ClF2O) contains a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 206.62 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
1-(Chloromethyl)-2-(2,2-difluoroethoxy)benzene (CAS 1178363-01-3) is a high-purity analytical reference standard with the molecular formula C9H9ClF2O and a molecular weight of 206.62 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-(Chloromethyl)-2-(2,2-difluoroethoxy)benzene meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H9ClF2O |
| Molecular Weight | 206.62 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/Cl-containing |
Related Chloromethyl Standards
- 1-(Chloromethyl)-4-(2,2-difluoroethoxy)benzene (CAS 1178393-11-7)
- 1-CHloromethyl-4-ethoxy-2,3-difluorobenzene (CAS 1771733-68-6)
- 6-(Chloromethyl)-3-(difluoromethyl)-5-methylpyridin-2-amine (CAS 1805219-57-1)
- 3-(Chloromethyl)-6-(difluoromethyl)-5-methylpyridin-2-amine (CAS 1805351-05-6)
- 6-(Chloromethyl)-3-(difluoromethyl)-4-methylpyridin-2-amine (CAS 1806789-76-3)
- 6-(Chloromethyl)-5-(difluoromethyl)-3-methylpyridin-2-amine (CAS 1806816-55-6)
- 3-(Chloromethyl)-6-(difluoromethyl)-4-methylpyridin-2-amine (CAS 1806894-26-7)
- 3-(Chloromethyl)-4-(difluoromethyl)-5-methylpyridin-2-amine (CAS 1806920-66-0)
Recommended Standards
- 1-(1-Chloroethyl)-4-(difluoromethoxy)benzene (CAS 1094302-39-2)
- 4-Chloro-7-fluoroquinoline-3-carbonitrile (CAS 622369-70-4)
- 1-CHloro-2,4-difluoro-5-(propan-2-yloxy)benzene (CAS 1394934-12-3)
- 4-Chloro-6-fluoroquinoline-3-carbonitrile (CAS 886362-73-8)
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- 7-Chloroisoquinolin-1-amine (CAS 1196154-21-8)
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- 2,5-Di(pyrrolidin-1-yl)cyclohexa-2,5-diene-1,4-dione (CAS 1521-03-5)
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- Nafcillin Impurity 84 (CAS CATO-C4X-33384)
- [1-(2-Fluoro-ethyl)-1h-pyrazol-3-yl]-methanol (CAS 1427021-99-5)
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