2',5'-Dichloro-5-fluoro-[1,1'-biphenyl]-2-carboxylic acid CAS 1178448-60-6

Purity 97%+In StockPharmaceutical Standards
CAS No.1178448-60-6
Molecular FormulaC13H7Cl2FO2
Molecular Weight285.10 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

2',5'-Dichloro-5-fluoro-[1,1'-biphenyl]-2-carboxylic acid CAS 1178448-60-6 chemical structure

Description

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

2',5'-Dichloro-5-fluoro-[1,1'-biphenyl]-2-carboxylic acid (CAS 1178448-60-6), molecular formula C13H7Cl2FO2 and molecular weight 285.10 g/mol, is a CATO reference standard with documented purity and traceability.

Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system, 2',5'-Dichloro-5-fluoro-[1,1'-biphenyl]-2-carboxylic acid is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 285.10 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

As a certified reference material (CRM), 2',5'-Dichloro-5-fluoro-[1,1'-biphenyl]-2-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC13H7Cl2FO2
Molecular Weight285.10 g/mol
AppearancePale yellow to yellow crystalline powder. (slight halide-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in chloroform, dichloromethane, ethyl acetate, DMSO
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)9.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1989
Halogen ContentF/Cl-containing

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