1-(Azetidin-3-yl)-4-(3-(trifluoromethyl)phenyl)piperazine trihydrochloride CAS 1184993-45-0
| CAS No. | 1184993-45-0 |
| Molecular Formula | C14H18F3N3 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 1-(Azetidin-3-yl)-4-(3-(trifluoromethyl)phenyl)piperazine trihydrochloride (C14H18F3N3HCl) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
1-(Azetidin-3-yl)-4-(3-(trifluoromethyl)phenyl)piperazine trihydrochloride (CAS 1184993-45-0) is a high-purity analytical reference standard with the molecular formula C14H18F3N3HCl and a molecular weight of 321.77 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-(Azetidin-3-yl)-4-(3-(trifluoromethyl)phenyl)piperazine trihydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H18F3N3 3*HCl |
| Molecular Weight | 321.77 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Azetidin Standards
- 4-(Azetidin-1-yl)cyclohexan-1-amine dihydrochloride (CAS 1001347-27-8)
- 4-(Azetidin-1-ylmethyl)-1H-indole (CAS 1001395-40-9)
- 2-(Azetidin-1-yl)acetic acid (CAS 1008304-81-1)
- Azetidin-3-yl methylcarbamate hydrochloride (CAS 1009368-29-9)
- 5-(Azetidin-3-yl)-2-methyl-tetrazole (CAS 1009409-58-8)
- 2-((Azetidin-3-yloxy)methyl)-5-methyl-1,3,4-oxadiazole (CAS 1009409-61-3)
- Azetidin-3-yl methylcarbamate (CAS 1009409-62-4)
- 1-(Azetidin-3-ylmethyl)piperidine (CAS 1012784-24-5)
Recommended Standards
- 6-Chloro-3-phenyl-[1,2,4]triazolo[4,3-a]pyridine (CAS 1258542-89-0)
- 1-(2-Chlorobenzyl)imidazolidine-2,4-dione (CAS 187243-31-8)
- (4-Aminopiperidin-1-yl)(cyclohex-3-en-1-yl)methanone (CAS 1154258-56-6)
- PTP1B-IN-2 (CAS 1919853-46-5)
- Methyl 2-(6-amino-1H-indazol-1-yl)acetate (CAS 316364-60-0)
- Verbenone (CAS 80-57-9)
- Z-Glu-OH (CAS 1155-62-0)
- N1,N3-Bis(2-chloroethyl)propane-1,3-diamine (CAS 73276-78-5)
- Poly-L-glutamine (CAS 26700-71-0)
- Semaglutide impurity 89 (CAS CATO-C4X-222689)
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