Sildenafil Impurity 40 CAS 1185292-79-8
| CAS No. | 1185292-79-8 |
| Molecular Formula | C8H13N3O |
| Molecular Weight | 167.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Sildenafil Impurity 40 (CAS 1185292-79-8, C8H13N3O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Sildenafil Impurity 40 (C8H13N3O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H13N3O |
| Molecular Weight | 167.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Nitrogen Atoms | 3 |
Related Sildenafil Standards
- Sildenafil Impurity 286 (CAS CATO-C4X-1128286)
- Sildenafil Impurity 39 (CAS 76424-56-1)
- Sildenafil Impurity 63 (CAS 247584-81-2)
- Sildenafil Pyrimidine Impurity (CAS 1346600-82-5)
- Sildenafil Impurity 42 (CAS 1441-87-8)
- Sildenafil Impurity 62 (CAS 116833-23-9)
- Sildenafil Impurity 64 (CAS 59023-32-4)
- Sildenafil Impurity 3 (CAS 139756-02-8)
Recommended Standards
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- D-dihydrophenylglycine Methyl Ester (CAS CATO-C4X-114883)
- Eravacycline impurity 35 (CAS CATO-C4X-293835)
- Fluticasone Impurity 66 (CAS 185536-05-4)
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- 8-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-3,3-dimethyl-N-phenyl-1,4,8-triazaspiro[4.5]Decane-1-carboxamide (CAS 338761-60-7)
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