4-(2,4-Difluorophenoxy)aniline hydrochloride CAS 1185295-53-7
| CAS No. | 1185295-53-7 |
| Molecular Formula | C12H9F2NO |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
4-(2,4-Difluorophenoxy)aniline hydrochloride (CAS 1185295-53-7), molecular formula C12H9F2NOHCl and molecular weight 257.66 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-(2,4-Difluorophenoxy)aniline hydrochloride (C12H9F2NOHCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), 4-(2,4-Difluorophenoxy)aniline hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H9F2NO HCl |
| Molecular Weight | 257.66 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Difluorophenoxy Standards
- 1-((2,4-Difluorophenoxy)methyl)-3,5-dimethyl-4-nitro-1H-pyrazole (CAS 1001519-18-1)
- Methyl 1-((2,4-difluorophenoxy)methyl)-1h-pyrazole-3-carboxylate (CAS 1004193-81-0)
- 2-(2,4-Difluorophenoxy)-3-methylbutanoic acid (CAS 1016734-04-5)
- 2-(2,4-difluorophenoxy)-2-phenylacetic acid (CAS 1016734-24-9)
- 4-(2,4-Difluorophenoxy)butan-1-amine (CAS 1016744-43-6)
- 2-(2,4-difluorophenoxy)pyridine-4-carboxylic acid (CAS 1019364-36-3)
- (4-(3,5-Difluorophenoxy)phenyl)boronic acid (CAS 1029438-51-4)
- [4-(2,3-difluorophenoxy)phenyl]methanol (CAS 1048358-65-1)
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- Des-His(1)-Semaglutide (CAS CATO-C4X-2226216)
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