(6-Methylpyridin-2-yl)(3,4,5-trifluorophenyl)methanone CAS 1187166-15-9
| CAS No. | 1187166-15-9 |
| Molecular Formula | C13H8F3NO |
| Molecular Weight | 251.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of (6-Methylpyridin-2-yl)(3,4,5-trifluorophenyl)methanone (C13H8F3NO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
(6-Methylpyridin-2-yl)(3,4,5-trifluorophenyl)methanone (CAS 1187166-15-9) is a high-purity analytical reference standard with the molecular formula C13H8F3NO and a molecular weight of 251.20 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H8F3NO |
| Molecular Weight | 251.20 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Methylpyridin Standards
- (4-Methylpyridin-2-yl)(3,4,5-trifluorophenyl)methanone (CAS 1187163-98-9)
- (3-Methylpyridin-2-yl)(3,4,5-trifluorophenyl)methanone (CAS 1187166-26-2)
- 2-Methyl-3-(3-methylpyridin-2-yl)quinazolin-4(3H)-one (CAS 3214-64-0)
- 4-[3-(6-Methylpyridin-3-yl)-1h-1,2,4-triazol-1-yl]aniline (CAS 1129541-11-2)
- 2-(3-Methylpyridin-2-yl)-4-phenylthiazole (CAS 1256482-99-1)
- 3-(4-(4-Methylpyridin-2-yl)piperazin-1-yl)propanoic acid (CAS 1285432-14-5)
- 2-(2-((4-Methylpyridin-2-yl)amino)thiazol-4-yl)acetic acid (CAS 1176779-50-2)
- 2-(2-((6-Methylpyridin-2-yl)amino)thiazol-4-yl)acetic acid (CAS 1283109-29-4)
Recommended Standards
- 2-Methyl-4-(3,4,5-trifluorobenzoyl)pyridine (CAS 1187164-94-8)
- 4-Methyl-3-(3,4,5-trifluorobenzoyl)pyridine (CAS 1187164-39-1)
- 2-(4-(Trifluoromethyl)phenyl)isonicotinaldehyde (CAS 1198794-20-5)
- Pyridin-2-yl(4-(trifluoromethyl)phenyl)methanone (CAS 122377-19-9)
- (9H-fluoren-9-yl)methyl (5-aminopentyl)carbamate hydrochloride (CAS 177333-17-4)
- Methyl 3-cyclopropyl-1-(4-fluorophenyl)-6-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate (CAS 1011397-19-5)
- [5-(Pyrrolidin-1-ylsulfonyl)-2-furyl]methylamine hydrochloride (CAS 1241675-86-4)
- 4-(1H-Imidazo[4,5-b]phenazin-2-yl)-N,N-dimethylaniline (CAS 2417-59-6)
- 3-Benzyl-2-fluoro-4-iodopyridine (CAS 655245-95-7)
- 8-(4,4,4-Trifluorobutyl)imidazo[1,2-a]pyrazine-6-carboximidamide (CAS 1838149-53-3)
- 5-Bromo-2-propoxybenzoyl chloride (CAS 343943-46-4)
- (3R,5R)-1-(tert-butoxycarbonyl)-5-(methoxycarbonyl)pyrrolidine-3-carboxylic acid (CAS 2227199-04-2)
- Sodium chlorofluoroacetate (CAS 70395-35-6)
- Hexapeptide-10 (CAS 146439-94-3)
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