6,8-Difluoro-chroman-4-ylamine hydrochloride CAS 1187928-83-1
| CAS No. | 1187928-83-1 |
| Molecular Formula | C9H9F2NO |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 6,8-Difluoro-chroman-4-ylamine hydrochloride (C9H9F2NOHCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
6,8-Difluoro-chroman-4-ylamine hydrochloride (CAS 1187928-83-1) is a high-purity analytical reference standard with the molecular formula C9H9F2NOHCl and a molecular weight of 221.63 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 6,8-Difluoro-chroman-4-ylamine hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H9F2NO HCl |
| Molecular Weight | 221.63 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Difluoro Standards
- 2-(4,5-Difluoro-2-nitrophenyl)acetic acid (CAS 1000339-22-9)
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Recommended Standards
- 2-(1-Isopropylpiperidin-4-yl)acetic acid (CAS 754183-67-0)
- 2-Methyl-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole hydrochloride (CAS 1112969-43-3)
- 5-Amino-2-(aminomethyl)pyridine (CAS 771574-03-9)
- (E)-3-methoxy-4-propoxybenzaldehyde oxime (CAS 571920-77-9)
- 1-(2-Nitrophenyl)azepane (CAS 40832-88-0)
- 5-(3-Bromophenoxy)pentanoic acid (CAS 87411-39-0)
- 5-(3,4-dihydro-2H-1,4-benzoxazin-6-yl)thiophene-2-carboxamide hydrochloride (CAS 1209773-69-2)
- 2-Cyclopentylacetamide (CAS 933-04-0)
- 2-(2-(3-Methyl-5-(trifluoromethyl)-1H-pyrazol-1-yl)thiazole-4-carbonyl)-N-(3-(trifluoromethyl)phenyl)hydrazine-1-carbothioamide (CAS 955966-44-6)
- Semaglutide impurity 25 (CAS CATO-C4X-222625)
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