5-Chloro-3-(3,5-difluorophenyl)isoxazole-4-carbaldehyde CAS 1188169-26-7
| CAS No. | 1188169-26-7 |
| Molecular Formula | C10H4ClF2NO2 |
| Molecular Weight | 243.59 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 5-Chloro-3-(3,5-difluorophenyl)isoxazole-4-carbaldehyde is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
5-Chloro-3-(3,5-difluorophenyl)isoxazole-4-carbaldehyde (CAS 1188169-26-7), molecular formula C10H4ClF2NO2 and molecular weight 243.59 g/mol, is a CATO reference standard with documented purity and traceability.
5-Chloro-3-(3,5-difluorophenyl)isoxazole-4-carbaldehyde (C10H4ClF2NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 5-Chloro-3-(3,5-difluorophenyl)isoxazole-4-carbaldehyde meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H4ClF2NO2 |
| Molecular Weight | 243.59 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 5-Chloro-3-(2,6-difluorophenyl)-1,2-oxazole-4-carbaldehyde (CAS 1188053-69-1)
- 5-Chloro-3-(2,4-difluorophenyl)-1,2-oxazole-4-carbaldehyde (CAS 1188135-97-8)
- 4-Chloro-6,8-difluoroquinoline-2-carboxylic acid (CAS 902742-65-8)
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- 3-(2-Chloro-6-nitrophenyl)-2-oxopropanoic acid (CAS 36892-19-0)
- 3-(4-Chloro-2-nitrophenyl)-2-oxopropanoic acid (CAS 71300-08-8)
- 3-(5-Chloro-2-nitrophenyl)-2-oxopropanoic acid (CAS 36255-90-0)
- 4-Chloro-2-(difluoromethyl)pyrido[3,2-d]pyrimidine-7-carbaldehyde (CAS 2770027-15-9)
Recommended Standards
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