4-Bromo-5,7-difluoro-2-propylquinoline CAS 1189106-83-9
| CAS No. | 1189106-83-9 |
| Molecular Formula | C12H10BrF2N |
| Molecular Weight | 286.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Bromo-5,7-difluoro-2-propylquinoline.
CATO supplies 4-Bromo-5,7-difluoro-2-propylquinoline (CAS 1189106-83-9), a certified reference material (molecular formula C12H10BrF2N, MW 286.12 g/mol) for analytical method development and quality control.
The molecular framework of 4-Bromo-5,7-difluoro-2-propylquinoline (C12H10BrF2N) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H10BrF2N |
| Molecular Weight | 286.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
- 4-Bromo-7,8-difluoro-2-propylquinoline (CAS 1189105-91-6)
- 4-Bromo-5,8-difluoro-2-propylquinoline (CAS 1189106-85-1)
- Methyl 2-(2-acetamido-4-bromophenyl)acetate (CAS 1182284-46-3)
- 4-Bromo-6,8-difluoro-2-propylquinoline (CAS 1189107-56-9)
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- tert-Butyl 5-bromo-8-iodo-3,4-dihydroisoquinoline-2(1H)-carboxylate (CAS 2922795-09-1)
- 4-Bromo-3-methyl-1,1’-biphenyl (CAS 92022-07-6)
- 2-(1-Chloro-2-methylpropyl)-5-methylfuran (CAS 917769-50-7)
- His-Aib-Semaglutide (CAS CATO-C4X-2226220)
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