3-[2,5-Bis(chloromethyl)-4-methoxy-phenoxy]propane-1-sulfonyl chloride CAS 118943-26-3

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-[2,5-Bis(chloromethyl)-4-methoxy-phenoxy]propane-1-sulfonyl chloride.

3-[2,5-Bis(chloromethyl)-4-methoxy-phenoxy]propane-1-sulfonyl chloride (CAS 118943-26-3) is a high-purity analytical reference standard with the molecular formula C12H15Cl3O4S and a molecular weight of 361.67 g/mol.

The molecular framework of 3-[2,5-Bis(chloromethyl)-4-methoxy-phenoxy]propane-1-sulfonyl chloride (C12H15Cl3O4S) is characterized by a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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