Aripiprazole EP Impurity B HCL CAS 119532-26-2
| CAS No. | 119532-26-2 |
| Molecular Formula | C10H12Cl2N2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Aripiprazole EP Impurity B HCL (CAS 119532-26-2), a pharmacopoeial impurity reference standard (molecular formula C10H12Cl2N2HCl, MW 267.58 g/mol) used for the identification and quantification of trace impurities in APIs.
Aripiprazole EP Impurity B HCL (C10H12Cl2N2HCl) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H12Cl2N2 HCl |
| Molecular Weight | 267.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Aripiprazole Standards
- Aripiprazole HCl (CAS 1026778-41-5)
- Aripiprazole Impurity N17 (CAS 1076199-56-8)
- Aripiprazole-d8 (CAS 1089115-04-7)
- Aripiprazole-d8 (CAS 1089115-06-9)
- Aripiprazole Impurity 32 (CAS 1147995-98-9)
- Aripiprazole-d (CAS 1185116-86-2)
- Aripiprazole Impurity 8 (CAS 120004-79-7)
- Aripiprazole Desethylene Impurity (CAS 1216394-63-6（free base）)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com