1-(Difluoromethoxy)-3-(trifluoromethyl)benzene CAS 119558-79-1
| CAS No. | 119558-79-1 |
| Molecular Formula | C8H5F5O |
| Molecular Weight | 212.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 212.12 g/mol gives 1-(Difluoromethoxy)-3-(trifluoromethyl)benzene distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies 1-(Difluoromethoxy)-3-(trifluoromethyl)benzene (CAS 119558-79-1), a certified reference material (molecular formula C8H5F5O, MW 212.12 g/mol) for analytical method development and quality control.
The molecular framework of 1-(Difluoromethoxy)-3-(trifluoromethyl)benzene (C8H5F5O) is characterized by a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 1-(Difluoromethoxy)-3-(trifluoromethyl)benzene meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H5F5O |
| Molecular Weight | 212.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
Related Difluoromethoxy Standards
- 1-(Difluoromethoxy)-2-(trifluoromethyl)benzene (CAS 1214388-57-4)
- 1-(Difluoromethoxy)-2-(difluoromethyl)-4-fluorobenzene (CAS 1261793-45-6)
- 4-(Difluoromethoxy)benzotrifluoride (CAS 156570-16-0)
- 7-(Difluoromethoxy)quinoxalin-2(1H)-one (CAS 1558746-87-4)
- 7-(difluoromethoxy)chromen-4-one (CAS 1918144-96-3)
- 5-(2-(Difluoromethoxy)phenyl)-2H-tetrazole (CAS 832737-43-6)
- 5-(4-difluoromethoxy-phenyl)-2h-tetraZole (CAS 832740-88-2)
- 3-(Difluoromethoxy)-1-fluoronaphthalene (CAS 1261729-28-5)
Recommended Standards
- (R)-1-(perfluorophenyl)ethan-1-ol (CAS 104371-21-3)
- 1-(Difluoromethyl)-3-(trifluoromethoxy)benzene (CAS 1214326-70-1)
- S(-)-1-(pentafluorophenyl)ethanol (CAS 104371-20-2)
- Nat 02-677 (CAS 54996-53-1)
- 1-(3-(2,2,2-Trifluoroethyl)phenyl)ethan-1-amine (CAS 1465485-52-2)
- 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-4-amine (CAS 2223044-20-8)
- 2-Chloro-1-(1-chlorocyclopropyl)ethanone (CAS 120983-72-4)
- 2-Bromo-N-dodecylacetamide (CAS 15537-87-8)
- (2S,4S)-(9H-Fluoren-9-yl)methyl 4-fluoro-2-(methoxy(methyl)carbamoyl)pyrrolidine-1-carboxylate (CAS 1235447-47-8)
- 5-Iodoquinolin-3-ol (CAS 1261803-72-8)
- 2,2-Dimethyl-5-(methylthio)pentanoic acid (CAS 1489337-98-5)
- Propyl β-Aminocrotonate (CAS 53055-18-8)
- 4-Bromo-2-methylbenzylamine Hydrochloride (CAS 1171381-49-9)
- (D-Trp32)-Neuropeptide Y (porcine) trifluoroacetate salt (CAS 153549-78-1)
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