2-((2-Amino-6-chloropyrimidin-4-yl)amino)-1-(pyrrolidin-1-yl)ethan-1-one CAS 1197639-88-5
| CAS No. | 1197639-88-5 |
| Molecular Formula | C10H14ClN5O |
| Molecular Weight | 255.70 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-((2-Amino-6-chloropyrimidin-4-yl)amino)-1-(pyrrolidin-1-yl)ethan-1-one (CAS 1197639-88-5) is a high-purity analytical reference standard with the molecular formula C10H14ClN5O and a molecular weight of 255.70 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, 2-((2-Amino-6-chloropyrimidin-4-yl)amino)-1-(pyrrolidin-1-yl)ethan-1-one is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 255.70 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H14ClN5O |
| Molecular Weight | 255.70 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Amino Standards
- 2-[(4-amino-2-chlorophenyl)formamido]-N,N-dimethylacetamide (CAS 1096794-02-3)
- 1-(4-(2-Amino-6-chloropyrimidin-4-yl)piperazin-1-yl)ethan-1-one (CAS 1197804-11-7)
- 2-(Boc-amino)-6-chlorobenzaldehyde (CAS 1260667-07-9)
- 1-(2-Amino-6-chloro-pyrimidin-4-yl)-piperidine-4-carboxylic acid amide (CAS 339017-63-9)
- 2-Amino-N-tert-butoxycarbonyl-5-chlorobenzaldehyde, 97% (CAS 260559-52-2)
- Ethyl 3-amino-4-chlorobenzo[b]thiophene-2-carboxylate (CAS 67189-92-8)
- Ethyl 2-(2-amino-6-chloro-9H-purin-9-yl)acetate (CAS 213552-03-5)
- 2-[4-(2-Amino-6-chlorophenyl)-1-piperazinyl]-1-ethanol (CAS 1155523-02-6)
Recommended Standards
- 3-(2-Chlorophenyl)-5-phenyl-1H-1,2,4-triazole (CAS 118863-81-3)
- (4-Chlorophenyl)(4,4-dihydroxypiperidin-1-yl)methanone (CAS 1161771-90-9)
- Methyl 1-(6-Chloro-3-pyridazinyl)piperidine-3-carboxylate (CAS 1208086-32-1)
- Ethyl (4-chlorobenzoyl)alaninate (CAS 1155848-58-0)
- 2-(Bromomethyl)-1-chloro-3,5-difluoro-4-methylbenzene (CAS 1858251-67-8)
- Clotiazepam Impurity 4 (CAS 50508-60-6)
- 2-(4-Chlorophenyl)-1H-indene-1,3(2H)-dione (CAS 1146-99-2)
- (6-(1H-1,2,4-Triazol-1-yl)pyridin-3-yl)boronic acid (CAS 883231-07-0)
- 1-(((4-Fluorophenyl)amino)methyl)cyclopentan-1-ol (CAS 1480447-62-8)
- 1-imino-3-methoxy-thietane 1-oxide (CAS 1609964-34-2)
- 5-Bromo-3-(2-methyl-3-nitrophenyl)-1H-indole (CAS 89346-29-2)
- Cefixime Impurity 107 (CAS CATO-C4X-1139107)
- N-Boc-5-methylpyrrolidine-2,4-dione (CAS 1450828-51-9)
- Semaglutide Impurity 124 (CAS CATO-C4X-2226124)
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