2,3-Dihydro-3-oxo-2-(tetrahydro-2H-pyran-4-yl)-N-[[4-(trifluoromethoxy)phenyl]methyl]-1H-Isoindole-1-carboxamide CAS 1198160-14-3
| CAS No. | 1198160-14-3 |
| Molecular Formula | C22H21F3N2O4 |
| Molecular Weight | 434.41 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2,3-Dihydro-3-oxo-2-(tetrahydro-2H-pyran-4-yl)-N-[[4-(trifluoromethoxy)phenyl]methyl]-1H-Isoindole-1-carboxamide (C22H21F3N2O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO supplies 2,3-Dihydro-3-oxo-2-(tetrahydro-2H-pyran-4-yl)-N-[[4-(trifluoromethoxy)phenyl]methyl]-1H-Isoindole-1-carboxamide (CAS 1198160-14-3), a certified reference material (molecular formula C22H21F3N2O4, MW 434.41 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H21F3N2O4 |
| Molecular Weight | 434.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Dihydro Standards
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Recommended Standards
- Aceclofenac Impurity 15 (CAS CATO-C4X-153115)
- 4-Nitrophenyl 2-(3-(trifluoromethyl)phenyl)-7-azaspiro[3.5]Nonane-7-carboxylate (CAS 1225276-30-1)
- Apixaban Impurity 181 (CAS CATO-C4X-1088181)
- 9-(2-Bromophenyl)-3,6-di-tert-butyl-9H-carbazole (CAS 1399743-51-1)
- (2R)-2-(dimethylamino)-3-phenylpropanoic acid (CAS 174222-78-7)
- 3-(4h-1,2,4-Triazole-3-carbonyl)pyridine (CAS 1483129-37-8)
- 7-Hydroxyisochroman-1-one (CAS 55104-41-1)
- Tert-butyl 4-(4-fluorophenyl)-3-hydroxypiperidine-1-carboxylate (CAS 1187171-99-8)
- 2-(Chloromethyl)phenethyl benzoate (CAS 168476-58-2)
- 4-Bromo-4'-(trifluoromethoxy)-1,1'-biphenyl (CAS 134150-03-1)
- 6-(4-Fluorophenyl)furo[2,3-d]pyrimidin-4-amine (CAS 744255-26-3)
- 5-(Chloromethyl)-3-methyl-4-nitroisoxazole (CAS 1835764-98-1)
- Piperidin-3-yl acetate (CAS 89122-73-6)
- Semaglutide impurity 268 (CAS CATO-C4X-2226268)
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