5-Methyl-1,3-thiazole-4-carbonyl chloride CAS 120237-77-6
| CAS No. | 120237-77-6 |
| Molecular Formula | C5H4ClNOS |
| Molecular Weight | 161.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 5-Methyl-1,3-thiazole-4-carbonyl chloride (C5H4ClNOS) is characterized by an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
5-Methyl-1,3-thiazole-4-carbonyl chloride (CAS 120237-77-6), molecular formula C5H4ClNOS and molecular weight 161.61 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H4ClNOS |
| Molecular Weight | 161.61 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Methyl Standards
- 2-Methyl-1,3-thiazole-5-carbonyl chloride (CAS 60971-72-4)
- 4-Methyl-1,3-thiazole-2-carbonyl chloride (CAS 79312-42-8)
- 4-Methyl-1,3-thiazole-5-carbonyl chloride (CAS 54237-09-1)
- 5-Methyl-1,3-thiazole-2-carbonyl chloride (CAS 61291-22-3)
- 1,3-Thiazole-2-sulfonamide (CAS 113411-24-8)
- Thiazole-4-sulfonamide (CAS 89501-97-3)
- Thiazole-5-sulfonamide (CAS 848362-05-0)
- Thiazole-2-sulfonic acid (CAS 172412-76-9)
Recommended Standards
- 4-Chlorothiophene-3-carboxamide (CAS 1174537-09-7)
- 3-Chloro-5-(methylthio)-1,2,4-triazine (CAS 1247802-89-6)
- 4-Amino-6-chloropyrimidine-2-thiol (CAS 116230-29-6)
- 2-Chloro-5-methylthiazole-4-carbaldehyde (CAS 1379296-36-2)
- (3-Bromo-4,5-dihydroisoxazol-5-yl)methanol (CAS 129097-92-3)
- 9-Octadecenedioic acid (CAS 4494-16-0)
- Benzyl 1H-indole-7-carboxylate (CAS 208774-33-8)
- 3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)phenol (CAS 2763160-08-1)
- N-[(1-Butyl-1,2,3,4-tetrahydroquinolin-6-yl)-methyl]-N-(2-furylmethyl)amine (CAS 1119453-02-9)
- 3-(4-Fluoro-3-methyl-5-(trifluoromethyl)phenyl)propanoic acid (CAS 1373920-73-0)
- 1-[2-(2-methylphenyl)-1,3-thiazol-5-yl]ethan-1-one (CAS 1226233-39-1)
- N-(2-Ethylphenyl)-N-[(4-methylphenyl)sulfonyl]glycine (CAS 335416-47-2)
- 3-Fluoroazetidine-3-methanol Hydrochloride (CAS 1803604-98-9)
- Liraglutide Impurity 28 (CAS CATO-C4X-199228)
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