1-(4-(Trifluoromethyl)phenyl)-6,7-dihydro-1H-indazol-4(5H)-one CAS 1203661-44-2
| CAS No. | 1203661-44-2 |
| Molecular Formula | C14H11F3N2O |
| Molecular Weight | 280.25 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 1-(4-(Trifluoromethyl)phenyl)-6,7-dihydro-1H-indazol-4(5H)-one is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 1-(4-(Trifluoromethyl)phenyl)-6,7-dihydro-1H-indazol-4(5H)-one (CAS 1203661-44-2), a certified reference material (molecular formula C14H11F3N2O, MW 280.25 g/mol) for analytical method development and quality control.
The molecular framework of 1-(4-(Trifluoromethyl)phenyl)-6,7-dihydro-1H-indazol-4(5H)-one (C14H11F3N2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-(4-(Trifluoromethyl)phenyl)-6,7-dihydro-1H-indazol-4(5H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H11F3N2O |
| Molecular Weight | 280.25 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Trifluoromethyl Standards
- 1-(3-(Trifluoromethyl)phenyl)-6,7-dihydro-1H-indazol-4(5H)-one (CAS 1203661-45-3)
- 2-Methyl-3'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid (CAS 1008773-97-4)
- Methyl 5-(trifluoromethyl)-[1,1'-biphenyl]-3-carboxylate (CAS 101640-74-8)
- 2-Methyl-2-(trifluoromethyl)-[1,1-biphenyl]-4-carboxylic acid (CAS 1140462-04-9)
- 2-(5-(trifluoromethyl)biphenyl-2-yl)acetic acid (CAS 1214346-33-4)
- 2-(3'-(Trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetic acid (CAS 1224742-15-7)
- 3'-Methyl-5-(trifluoromethyl)-[1,1'-biphenyl]-3-carboxylic acid (CAS 1261953-10-9)
- MEthyl 3'-(trifluoromethyl)[1,1'-biphenyl]-4-carboxylate (CAS 127783-72-6)
Recommended Standards
- 5-(2-(4-Fluorophenyl)acetyl)-2,2-dimethyl-1,3-dioxane-4,6-dione (CAS 1174047-11-0)
- N-methyl-2-(5-(trifluoromethyl)pyridin-2-yl)benzamide (CAS 1092345-87-3)
- 3-(3,5-Difluorophenyl)thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione (CAS 1255776-63-6)
- (E)-Methoxy({4-[4-(trifluoromethyl)pyridin-2-yl]phenyl}methylidene)amine (CAS 1092343-99-1)
- 62134-52-5 4-[(3-acetylphenyl)amino]-4-oxobutanoic acid DTXSID90352267 (CAS 62134-52-5)
- 3-Amino-4-hydroxy-5-methoxybenzonitrile (CAS 1362094-92-5)
- 1-(O-tolyl)-1H-imidazole-4-carboxamide (CAS 1427015-21-1)
- 1-Isopropyl-3-(trifluoromethyl)-1H-pyrazol-4-amine (CAS 2005442-46-4)
- Ethyl 2-(Bromomethyl)thiazole-5-carboxylate (CAS 173089-24-2)
- Methyl 4-amino-4-(2,4-difluorophenyl)butanoate (CAS 1178716-80-7)
- 1,1-Difluoro-6-(4-methoxyphenyl)hex-5-ene-2,4-dione (CAS 941866-52-0)
- methyl 3-chloro-2-oxo-3-phenylpropanoate (CAS 32803-73-9)
- 3-(Ethylsulfonyl)-4-(p-tolyl)-1H-pyrazole (CAS 1707374-32-0)
- Fibrinopeptide A, human TFA (CAS 61533-47-9)
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