1-(3-(Difluoromethoxy)phenyl)guanidine CAS 1204296-41-2
| CAS No. | 1204296-41-2 |
| Molecular Formula | C8H9F2N3O |
| Molecular Weight | 201.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-(3-(Difluoromethoxy)phenyl)guanidine.
1-(3-(Difluoromethoxy)phenyl)guanidine (CAS 1204296-41-2) is a high-purity analytical reference standard with the molecular formula C8H9F2N3O and a molecular weight of 201.17 g/mol.
1-(3-(Difluoromethoxy)phenyl)guanidine (C8H9F2N3O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H9F2N3O |
| Molecular Weight | 201.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Difluoromethoxy Standards
- (E)-1-(3-(Difluoromethoxy)phenyl)ethan-1-one oxime (CAS 1245782-73-3)
- (E)-1-(4-(Difluoromethoxy)phenyl)ethan-1-one oxime (CAS 149774-14-1)
- N-(2-(difluoromethoxy)phenyl)acetamide (CAS 22236-05-1)
- 2-(2-(Difluoromethoxy)-6-fluorophenyl)acetonitrile (CAS 1261862-28-5)
- 7-(Difluoromethoxy)benzo[d]isothiazole (CAS 147317-40-6)
- 2-(Difluoromethoxy)-5-hydroxybenzo[d]oxazole (CAS 1803740-96-6)
- 4-(Difluoromethoxy)benzo[d]oxazol-2-ol (CAS 1803812-11-4)
- 2-(Difluoromethoxy)-4-hydroxybenzo[d]oxazole (CAS 1806281-79-7)
Recommended Standards
- 4-fluorobenzo[d]isothiazol-3(2H)-one 1,1-dioxide (CAS 120257-03-6)
- (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-4-yl)ethan-1-amine (CAS 1213203-92-9)
- 2-(2,5-Difluorophenyl)-2-(methylamino)acetic acid (CAS 1192660-36-8)
- (1S)-1-(2,2-difluorobenzo[d]1,3-dioxolen-4-yl)ethylamine (CAS 1213390-36-3)
- 2-Methyloxazolo[4,5-c]quinoline (CAS 15260-89-6)
- N-(4-Fluorophenyl)-2-[4-(5-methyl-1,2,4-oxadiazol-3-yl)-1,3-dioxo-1H,2H,3H,5H,6H,7H,8H-pyrido[1,2-c]pyrimidin-2-yl]acetamide (CAS 1775402-77-1)
- (2-(4-Bromophenyl)oxazol-4-yl)methanamine (CAS 724412-56-0)
- 3-(Pyrimidin-4-yl)propanal (CAS 944898-43-5)
- 1-(Piperidin-4-yl)propan-2-ol hydrochloride (CAS 1126084-45-4)
- Amisulpride Impurity 47 (CAS CATO-C4X-104547)
- 2-Amino-4-(benzyloxy)-3-methoxybenzonitrile (CAS 1032570-65-2)
- 2-(3-(2-Chloroethyl)ureido)-N,N-dimethylethane-1-sulfonamide (CAS 91893-26-4)
- 2-(Difluoromethyl)-3-hydroxy-5-iodo-4-nitropyridine (CAS 1807132-34-8)
- Semaglutide Impurity 123 (CAS 71997-93-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com