2-(4-Fluorophenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole hydrochloride CAS 1205637-49-5
| CAS No. | 1205637-49-5 |
| Molecular Formula | C13H14FN3O |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(4-Fluorophenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole hydrochloride (CAS 1205637-49-5), molecular formula C13H14FN3OHCl and molecular weight 283.73 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-(4-Fluorophenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole hydrochloride (C13H14FN3OHCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H14FN3O HCl |
| Molecular Weight | 283.73 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Fluorophenyl Standards
- 3-[(3-fluorophenyl)methyl]pyrrolidine (CAS 1000198-80-0)
- 3-(3-Fluorophenyl)-3-oxopropanoic acid (CAS 1000530-96-0)
- Ethyl 1-(4-fluorophenyl)-5-oxo-2,5-dihydro-1H-1,2,4-triazole-3-carboxylate (CAS 1000573-68-1)
- 1000574-26-4 2-(4-Fluorophenyl)-6-methylthio-4H-thiopyran-4-one MFCD09877819 (CAS 1000574-26-4)
- Ethyl 1-(2-fluorophenyl)-5-oxo-2,5-dihydro-1H-1,2,4-triazole-3-carboxylate (CAS 1000575-18-7)
- 100074-04-2 5-(4-Fluorophenyl)-1-pentene MFCD11553774 (CAS 100074-04-2)
- 3-(2-Fluorophenyl)-4-hydroxyfuran-2(5H)-one (CAS 100074-44-0)
- N-[2-(4-fluorophenyl)ethyl]-1H-imidazole-1-carboxamide (CAS 1000931-75-8)
Recommended Standards
- 2-(Chloromethyl)-1,3,5-trifluorobenzene (CAS 247564-62-1)
- Ocimene Quintoxide (CAS 7416-35-5)
- 1-(4-Bromophenyl)-3-propylurea (CAS 13208-61-2)
- 3-(4-Amino-5-methyl-1h-pyrazol-1-yl)tetrahydrothiophene 1,1-dioxide (CAS 1251362-57-8)
- Tert-butyl 7-bromo-6-nitro-3,4-dihydroisoquinoline-2(1H)-carboxylate (CAS 186390-63-6)
- 1-(Naphthalen-1-yloxy)propan-2-ol (CAS 91909-71-6)
- Morpholino(piperazin-1-yl)methanone (CAS 98834-08-3)
- 3-[(2-cyanoethyl)(methyl)sulfamoyl]benzoic acid (CAS 735337-12-9)
- 9-((4,4,5,5,5-Pentafluoropentyl)thio)nonan-1-ol (CAS 511545-94-1)
- Nonapeptide-1 (CAS 158563-45-2)
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