8-Chloro-5-methoxy-2-methyl-4-quinolinol CAS 1206-62-8
| CAS No. | 1206-62-8 |
| Molecular Formula | C11H10ClNO2 |
| Molecular Weight | 223.66 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
8-Chloro-5-methoxy-2-methyl-4-quinolinol (CAS 1206-62-8) is a high-purity analytical reference standard with the molecular formula C11H10ClNO2 and a molecular weight of 223.66 g/mol.
The molecular framework of 8-Chloro-5-methoxy-2-methyl-4-quinolinol (C11H10ClNO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H10ClNO2 |
| Molecular Weight | 223.66 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
- 4-Chloro-3-(3-ethyl-1,2,4-oxadiazol-5-yl)aniline (CAS 1183472-79-8)
- 6-Chloro-8-methoxy-2-methylquinolin-4-ol (CAS 1206-97-9)
- 5-(2-Chloroacetyl)-1-methyl-2,3-dihydro-1h-indol-2-one (CAS 118306-97-1)
- 1-Chloro-6,8-dimethoxyisoquinoline (CAS 1206975-08-7)
- 1-Isobutyl-1H-pyrazol-5-ol (CAS 267882-22-4)
- 2-(Difluoromethoxy)-3-fluoropyridine (CAS 1214377-43-1)
- 2,4,5-Trifluoropyridine (CAS 837365-04-5)
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- 2-Chlorotrityl chloride resin (200-400 mesh, 1.5-1.9 mmol/g) (CAS 934816-82-7)
- (8-Azabicyclo[3.2.1]oct-2-en-8-yl)(5-methylisoxazol-3-yl)methanone (CAS 1797904-42-7)
- 3-(4-Allyl-2-methoxyphenoxy)pyrrolidinehydrochloride (CAS 1220016-93-2)
- 4-(O-tolyl)tetrahydro-2H-pyran-4-amine (CAS 1094341-11-3)
- N-((5-Bromo-2-chloropyridin-4-yl)methylene)-2-methylpropan-2-amine (CAS 1382848-39-6)
- Semaglutide Impurity 140 (CAS CATO-C4X-2226140)
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