1-Chloro-7-fluoro-3-methylisoquinoline CAS 1206982-03-7
| CAS No. | 1206982-03-7 |
| Molecular Formula | C10H7ClFN |
| Molecular Weight | 195.62 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 195.62 g/mol gives 1-Chloro-7-fluoro-3-methylisoquinoline distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
1-Chloro-7-fluoro-3-methylisoquinoline (CAS 1206982-03-7) is a high-purity analytical reference standard with the molecular formula C10H7ClFN and a molecular weight of 195.62 g/mol.
The molecular framework of 1-Chloro-7-fluoro-3-methylisoquinoline (C10H7ClFN) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 1-Chloro-7-fluoro-3-methylisoquinoline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H7ClFN |
| Molecular Weight | 195.62 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 4-Chloro-5-fluoro-8-methylquinoline (CAS 1065093-43-7)
- 4-Chloro-6-fluoro-8-methylquinoline (CAS 1065093-47-1)
- 4-Chloro-7-fluoro-8-methylquinoline (CAS 1065093-51-7)
- 2-Chloro-8-fluoro-4-methylquinoline (CAS 1171919-59-7)
- 1-(3-Chloro-4-fluorophenyl)cyclopropanecarbonitrile (CAS 1205640-59-0)
- 1-(2-Chloro-6-fluorophenyl)cyclopropanecarbonitrile (CAS 124276-45-5)
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- 1-(4-Chloro-2-fluorophenyl)cyclopropane-1-carbonitrile (CAS 1260750-70-6)
Recommended Standards
- 2-(Chloromethyl)-6-fluoroquinoline (CAS 124050-15-3)
- 1-(3-Chloro-2-fluorophenyl)cyclopropanecarbonitrile (CAS 1260762-74-0)
- 1-(chloromethyl)-2-fluoro-3-nitrobenzene (CAS 1020718-00-6)
- 1-(4-Chloro-3-fluorophenyl)cyclopropane-1-carbonitrile (CAS 1265476-80-9)
- 4-Amino-4-(2-bromo-4-methoxyphenyl)butanoic acid (CAS 1184608-84-1)
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- Ethyl 8-(3-fluorophenyl)-8-oxooctanoate (CAS 898752-14-2)
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- N1-benzyl-N3,N3,2,2-tetramethylpropane-1,3-diamine (CAS 858010-15-8)
- Semaglutide impurity 60 (CAS CATO-C4X-222660)
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