1-Bromo-2-chloro-3-methoxy-5-methylbenzene CAS 1208075-75-5
| CAS No. | 1208075-75-5 |
| Molecular Formula | C8H8BrClO |
| Molecular Weight | 235.51 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1-Bromo-2-chloro-3-methoxy-5-methylbenzene (CAS 1208075-75-5) is a high-purity analytical reference standard with the molecular formula C8H8BrClO and a molecular weight of 235.51 g/mol.
The molecular framework of 1-Bromo-2-chloro-3-methoxy-5-methylbenzene (C8H8BrClO) is characterized by a hydroxyl group, an ether linkage, chlorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H8BrClO |
| Molecular Weight | 235.51 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl/Br-containing |
Related Bromo Standards
- 1-(4-Bromo-2-chlorophenyl)ethan-1-ol (CAS 1002309-96-7)
- 1-Bromo-3-chloro-2-ethoxy-benzene (CAS 1010390-50-7)
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- 4-Bromo-3-chloro-2-methylanisole (CAS 1155264-58-6)
Recommended Standards
- 1-(2-Bromo-6-chlorophenyl)ethan-1-ol (CAS 1175300-45-4)
- 1-Bromo-4-chloro-5-methoxy-2-methylbenzene (CAS 1208077-43-3)
- 1-Bromo-4-chloro-2-(methoxymethyl)benzene (CAS 1208318-88-0)
- (1s)-2-Bromo-1-(2-chlorophenyl)ethan-1-ol (CAS 1212322-23-0)
- 6-((Cyclopentyl(methyl)amino)methyl)benzo[d][1,3]dioxol-5-ol (CAS 931059-96-0)
- (1-(((Benzyloxy)carbonyl)amino)-3-phenylpropyl)phosphinic acid (CAS 234452-57-4)
- Columbamine (CAS 3621-36-1)
- 2-[(3-chlorophenyl)methoxy]acetic acid (CAS 868277-51-4)
- 3-(1-Ethylpiperidin-2-yl)-2-(pyrrolidin-1-yl)pyridine (CAS 1352484-86-6)
- 2-(Difluoromethyl)-6-methoxy-3-nitro-5-(trifluoromethoxy)pyridine (CAS 1804791-56-7)
- Suberic anhydride (CAS 10521-06-9)
- Tert-butyl 2-hydroxy-9-oxo-6-azaspiro[3.5]Nonane-6-carboxylate (CAS 2387598-90-3)
- 1-(Trifluoromethyl)cyclopropane-1-carbothioamide (CAS 871913-36-9)
- Semaglutide Impurity 142 (CAS CATO-C4X-2226142)
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