4-Chloro-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine CAS 1211520-73-8
| CAS No. | 1211520-73-8 |
| Molecular Formula | C7H3ClF3N3 |
| Molecular Weight | 221.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Chloro-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine.
4-Chloro-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine (CAS 1211520-73-8) is a high-purity analytical reference standard with the molecular formula C7H3ClF3N3 and a molecular weight of 221.57 g/mol.
4-Chloro-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine (C7H3ClF3N3) contains a nitrile group, fluorine/chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Chloro-5-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H3ClF3N3 |
| Molecular Weight | 221.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 7-Chloro-5-(trifluoromethyl)-1H-pyrazolo[4,3-b]pyridine (CAS 100478-05-5)
- 4-Chloro-2-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine (CAS 1060815-85-1)
- 4-Chloro-6-(trifluoromethyl)-1,2,3-benzotriazole (CAS 1086836-70-5)
- 6-Chloro-2-(trifluoromethyl)imidazo[1,2-b]pyridazine (CAS 109113-97-5)
- 2-Chloro-5-(trifluoromethyl)-3H-imidazo[4,5-b]pyridine (CAS 114087-69-3)
- 3-Chloro-6-(trifluoromethyl)-1H-pyrazolo[4,3-b]pyridine (CAS 1211518-18-1)
- 8-Chloro-5-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine (CAS 1260860-23-8)
- 6-Chloro-2-(trifluoromethyl)-3H-imidazo[4,5-b]pyridine (CAS 13577-71-4)
Recommended Standards
- 2-Amino-3-chloro-5-(trifluoromethyl)isonicotinonitrile (CAS 1221572-26-4)
- 1-azido-4-chloro-2-(trifluoromethyl)benzene (CAS 1152586-17-8)
- 5-Chloro-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine (CAS 1402665-00-2)
- 6-Chloro-3-(trifluoromethyl)-1H-pyrazolo[4,3-c]pyridine (CAS 1431720-68-1)
- (R)-2-Amino-3-(1H-indol-3-yl)propan-1-ol hydrochloride (CAS 1251033-63-2)
- Fmoc-D-n(Trt)-OH (CAS 10417-83-1)
- 1,3-Diphenylguanidine (CAS 102-06-7)
- 4-Bromo-2-(difluoromethyl)-3-nitropyridine-5-acetonitrile (CAS 1805379-79-6)
- Hexaphenylditin, 99+% (CAS 1064-10-4)
- (1-Fluorocyclopentyl)methanamine hydrochloride (CAS 1462885-83-1)
- 2-(4-Chlorophenyl)-3-(trifluoromethyl)pyrazole-4-carboxylic acid hydrazide (CAS 175137-34-5)
- QBP25342AG 75621-03-3 CHAPS 3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate 1-Propanaminium, N,N-dimethyl-N-(3-sulfopropyl)-3-(((3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)-, hydroxide, inner salt 3-((3-Cholamidopropyl)dimethylammonio)-1-propanesulfonate Cholic acid sulfobetaine1-propanaminium, N,N-dimethyl-3-sulfo-N-(3-(((3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)propyl)-, hydroxide, inner salt 1-Propanaminium, N,N-dimethyl-3-sulfo-N-(3-(((3alpha,5beta,7alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)propyl)-,hydroxide, inner salt UNII-QBP25342AG (CAS 75621-03-3)
- 3-bromo-1H-pyrazolo[3,4-c]pyridine-5-carboxylic acid (CAS 1784634-07-6)
- [β-Asp]9-Semaglutide (CAS CATO-CPTD788605)
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