6-Cyano-2-(trifluoromethyl)nicotinic acid CAS 1211537-27-7
| CAS No. | 1211537-27-7 |
| Molecular Formula | C8H3F3N2O2 |
| Molecular Weight | 216.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 6-Cyano-2-(trifluoromethyl)nicotinic acid (CAS 1211537-27-7), a certified reference material (molecular formula C8H3F3N2O2, MW 216.12 g/mol) for analytical method development and quality control.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, 6-Cyano-2-(trifluoromethyl)nicotinic acid is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 216.12 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 6-Cyano-2-(trifluoromethyl)nicotinic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H3F3N2O2 |
| Molecular Weight | 216.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Cyano Standards
- 5-Cyano-2-(trifluoromethyl)nicotinic acid (CAS 1211537-37-9)
- 6-Cyano-5-(trifluoromethyl)nicotinic acid (CAS 1360916-76-2)
- 2-Cyano-6-(trifluoromethyl)isonicotinic acid (CAS 1393552-13-0)
- 2-Cyano-5-(trifluoroacetylamino)pyrimidine (CAS 1434128-53-6)
- 5-cyano-6-(trifluoromethyl)pyridine-3-carboxylic acid (CAS 1803813-92-4)
- 4-Cyano-2-(difluoromethyl)-5-fluoronicotinic acid (CAS 1804487-37-3)
- 4-Cyano-3-(difluoromethyl)-2-fluoropyridine-5-carboxylic acid (CAS 1804487-43-1)
- 4-Cyano-6-(difluoromethyl)-3-fluoropyridine-2-carboxylic acid (CAS 1805085-70-4)
Recommended Standards
- n-[(3,4-dichlorophenyl)methyl]cyclopropanamine (CAS 90919-75-8)
- n-(2,6-Dichlorobenzyl)cyclopropanamine (CAS 892569-22-1)
- 3-Nitro-4-(trifluoromethyl)benzonitrile (CAS 1227489-72-6)
- n-(2,4-Dichlorobenzyl)cyclopropanamine (CAS 892568-95-5)
- 1-Amino-4-(tert-butyl)cyclohexanecarboxylic acid (CAS 18672-76-9)
- Tert-butyl 3-amino-1-methyl-1H-pyrazole-5-carboxylate (CAS 1379353-30-6)
- 6-Bromo-2-fluoro-3-iodobenzoic acid (CAS 217816-53-0)
- 2-[1-(3,4-Dichlorobenzyl)-2-oxo-5-(thiomorpholinosulfonyl)indolin-3-ylidene]malononitrile (CAS 1144853-65-5)
- 1185105-86-5 4-(3-Piperidinyl)pyrimidine dihydrochloride MFCD12028541 (CAS 1185105-86-5)
- 2-(difluoromethyl)-3,5-dimethyl-1H-pyrrole (CAS 2756415-03-7)
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- 1-(2-(4-Chlorophenyl)-4-methylthiazol-5-yl)ethan-1-one (CAS 54001-07-9)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com