8-Methyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine CAS 1211585-17-9
| CAS No. | 1211585-17-9 |
| Molecular Formula | C10H11F3N2 |
| Molecular Weight | 216.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 8-Methyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine (C10H11F3N2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO supplies 8-Methyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine (CAS 1211585-17-9), a certified reference material (molecular formula C10H11F3N2, MW 216.20 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H11F3N2 |
| Molecular Weight | 216.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Methyl Standards
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- (2-(3-(Trifluoromethyl)phenyl)cyclopropyl)methanol (CAS 1188541-93-6)
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Recommended Standards
- 7-Amino-5-methylpyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-6(7H)-one (CAS 1211268-44-8)
- (R)-3-(Pyrrolidin-2-yl)-2-(trifluoromethyl)pyridine (CAS 1212838-38-4)
- (S)-3-(Pyrrolidin-2-yl)-5-(trifluoromethyl)pyridine (CAS 1213536-99-2)
- 2-(Pyrrolidin-3-yl)-5-(trifluoromethyl)pyridine (CAS 1196146-55-0)
- 2-[(2-Methylphenyl)sulfanyl]-5-(trifluoromethyl)benzenecarbonitrile (CAS 477866-93-6)
- 3-Benzoimidazol-1-yl-propionitrile (CAS 4414-84-0)
- 1-(4-Isopropoxybenzyl)piperazine (CAS 21867-72-1)
- {[2-(4-fluorophenyl)-1,3-thiazol-4-yl]methyl}(methyl)amine (CAS 1153070-05-3)
- (4-Methylmorpholin-2-yl)methanamine hydrochloride (CAS 1290614-59-3)
- N-Nitrosodiisopropylamine- d14 (CAS 2975202-11-8)
- 6,8-Dimethylquinolin-3-ol (CAS 122130-53-4)
- 4-Chloro-6-((4-chlorophenyl)thio)-2-(methylthio)pyrimidine (CAS 339017-71-9)
- 2-(2-Methoxyphenoxy)-N-methyl-1-propanamine (CAS 1040686-56-3)
- Gly-Neuroendocrine Regulatory Peptide-3 (human, mouse, rat) trifluoroacetate salt (CAS 1815618-19-9)
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