4-(3-Aminophenoxy)-5-chloro-N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)pyrimidin-2-amine CAS 1213269-26-1
| CAS No. | 1213269-26-1 |
| Molecular Formula | C22H25ClN6O2 |
| Molecular Weight | 440.93 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(3-Aminophenoxy)-5-chloro-N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)pyrimidin-2-amine.
4-(3-Aminophenoxy)-5-chloro-N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)pyrimidin-2-amine (CAS 1213269-26-1), molecular formula C22H25ClN6O2 and molecular weight 440.93 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C22H25ClN6O2, 4-(3-Aminophenoxy)-5-chloro-N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)pyrimidin-2-amine contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 440.93 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 4-(3-Aminophenoxy)-5-chloro-N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)pyrimidin-2-amine under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H25ClN6O2 |
| Molecular Weight | 440.93 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Aminophenoxy Standards
- 4-(3-aminophenoxy)-N-(4-(4-methylpiperazin-1-yl)phenyl)thieno[3,2-d]pyrimidin-2-amine (CAS 1353553-09-9)
- Bis[4-(3-aminophenoxy)phenyl] Sulfone (CAS 30203-11-3)
- (S)-3-(4-Aminophenoxy)-N-((4-cyano-3-(trifluoromethyl)phenyl)carbamoyl)-2-hydroxy-2-methylpropanamide (CAS 850218-75-6)
- 4-(4-(4-Aminophenoxy)phenyl)-2-(4-aminophenyl)phthalazin-1(2H)-one (CAS 228086-34-8)
- 2,2-Bis[4-(3-aminophenoxy)pheny]propane (CAS 87880-61-3)
- 1,3,5-Tris(4-aminophenoxy)benzene (CAS 102852-92-6)
- 5-(4-Aminophenoxy)-2-(2-(trifluoromethyl)phenyl)isoindoline-1,3-dione (CAS 310451-99-1)
- 5-(4-Aminophenoxy)-2-[3-(trifluoromethyl)-phenyl]-1H-isoindole-1,3(2H)-dione (CAS 310451-95-7)
Recommended Standards
- Losartan Carboxylic Acid-d4 (CAS 1246820-62-1)
- 3-(4-Chlorophenyl)-5-(4-phenylpiperazin-1-yl)-[1,2,4]triazolo[4,3-c]quinazoline (CAS 338793-00-3)
- N-(3-Chloro-4-(naphthalen-2-yloxy)phenyl)-6-methoxy-2-methylquinolin-4-amine (CAS 305866-70-0)
- (3-Amino-4,6-diphenylthieno[2,3-b]pyridin-2-yl)(4-chlorophenyl)methanone (CAS 94360-99-3)
- (E)-1-(7-(2-(dimethylamino)vinyl)-2-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)ethan-1-one (CAS 1306753-52-5)
- 6-Chloro-2-(5-ethylthiophen-2-yl)quinoline-4-carboxylic acid (CAS 438215-52-2)
- 6,7-Dimethyl-1H-pyrrolo[3,2-b]pyridin-2(3H)-one (CAS 1190320-04-7)
- Methyl 2-amino-6-ethyl-4,5,6,7-tetrahydrothieno[2,3-b]pyridine-3-carboxylate (CAS 1017794-06-7)
- 1-(4-Fluoro-3-nitrophenyl)-4-methylpiperazine (CAS 1216614-11-7)
- 2,5-Dioxaspiro[3.5]Nonan-7-ol (CAS 2306261-12-9)
- Methyl 2-(5-methyl-3-nitro-1h-pyrazol-1-yl)propanoate (CAS 1005577-00-3)
- 2-(3-Aminopyrrolidin-1-yl)-5,6,7,8-tetrahydroquinazolin-4(3H)-one (CAS 1240674-38-7)
- 1-(2,4-Dimethylphenyl)-N-methylmethanamine hydrochloride (CAS 470692-25-2)
- Tirzepatide Impurity 37 (CAS CATO-C4X-324037)
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